{"id":"W4414825558","doi":"10.1016/j.euroneuro.2025.08.507","title":"MAPPING CELL TYPE-SPECIFIC EPIGENETIC REGULATION IN DORSOLATERAL PREFRONTAL CORTEX (DLPFC) TO UNCOVER MOLECULAR MECHANISMS IN PSYCHIATRIC DISORDERS","year":2025,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Birth, Development, and Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health","funders":"","keywords":"Genome-wide association study; Epigenetics; Dorsolateral prefrontal cortex; Epigenomics; Chromatin; Regulation of gene expression; Gene expression; Gene regulatory network; DNA methylation; Prefrontal cortex","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001552057,0.00009841516,0.0001571876,0.0002720119,0.0001437008,0.0002601706,0.0002171157,0.0001889217,0.001259568],"category_scores_gemma":[0.0001925186,0.0001045623,0.0001913505,0.0001769114,0.0002840859,0.000182914,0.000225461,0.0002939729,0.000106882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003480359,"about_ca_system_score_gemma":0.0002844065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002716136,"about_ca_topic_score_gemma":0.00774244,"domain_scores_codex":[0.9999142,0.000009452124,0.000002497756,0.00002846723,0.00001663025,0.00002867726],"domain_scores_gemma":[0.999943,0.000009400973,0.00001996217,0.000007721828,0.000009446565,0.00001057655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003487006,0.0000416228,0.02490352,0.00006855585,0.00008933348,0.0001415164,0.0001728363,0.0003410142,0.9491933,0.001103903,0.0002094446,0.02338623],"study_design_scores_gemma":[0.00005796621,0.0003016572,0.7385778,0.00003506214,0.0001581351,0.0009041311,0.0005921369,0.003432125,0.248424,0.002534219,0.004962086,0.00002070751],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987193,0.001847069,0.008697159,0.0002508276,0.00003113981,0.00001689094,0.0004020626,0.00003295877,0.001528813],"genre_scores_gemma":[0.996958,0.0003783062,0.001675868,0.00008163795,0.000005448068,0.0000100264,0.00009939967,0.000008307454,0.0007831155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002716136,"threshold_uncertainty_score":0.005400658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036546540913552,"score_gpt":0.2751174476539269,"score_spread":0.2647519822447914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}