{"id":"W4414827377","doi":"10.1101/2025.10.03.680374","title":"Molecular determinants underlying functional divergence of TBP homologs","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Stem Cell Network","keywords":"RNA; Gene; Functional divergence; Transcription factor II D; Complementation; RNA polymerase II; RNA-binding protein; Transcription (linguistics); Homologous chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009943441,0.000164974,0.0001488444,0.0002422867,0.0001072476,0.0002397792,0.0002130992,0.0002406475,0.001140882],"category_scores_gemma":[0.0002328939,0.0001102338,0.0001250615,0.0001449421,0.000240274,0.0001388675,0.0003117993,0.0004958147,0.0003988114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001445165,"about_ca_system_score_gemma":0.00006408701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001463057,"about_ca_topic_score_gemma":0.0001263808,"domain_scores_codex":[0.9999135,0.00001232076,0.000007949359,0.00002888656,0.00001884216,0.0000184907],"domain_scores_gemma":[0.9997488,0.00005425947,0.00006453797,0.0000242969,0.00002314119,0.00008493799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004538872,0.00000635377,0.0008293687,0.000008234444,0.000002478077,0.00006512817,0.000009277591,0.00002146262,0.9985601,0.00006261474,0.000007570126,0.000381967],"study_design_scores_gemma":[0.00003505358,0.0003213979,0.1448688,0.00001444342,0.00003016452,0.002751114,0.0001406568,0.002161232,0.8463094,0.0004647373,0.002889402,0.00001356307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998826,0.0001918688,0.0005845615,0.00001775357,0.000003152561,0.000003068928,0.0001623371,0.00001006576,0.0002012324],"genre_scores_gemma":[0.9987316,0.00005964693,0.0004055666,0.00001872865,0.000003118692,0.000006792901,0.0004771429,0.00001182171,0.0002855826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001140882,"threshold_uncertainty_score":0.003816664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02998900188872266,"score_gpt":0.2680115795901503,"score_spread":0.2380225777014277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}