{"id":"W4414829504","doi":"10.1111/pbi.70386","title":"Single Cell Multi‐Omics Reveals Rare Biosynthetic Cell Types in the Medicinal Tree <scp> <i>Camptotheca acuminata</i> </scp>","year":2025,"lang":"en","type":"article","venue":"Plant Biotechnology Journal","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus","funders":"Natural Sciences and Engineering Research Council of Canada; Genomics Center, University of Minnesota; University of Minnesota; University of California, Davis; Georgia Research Alliance; University of Georgia; National Science Foundation","keywords":"Camptothecin; Chromatin; Topoisomerase; Biosynthesis; Cell; Gene; Enzyme; Genomics; Cell type","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002777292,0.0003623045,0.0007696075,0.0006677649,0.0006729734,0.001312079,0.0003412513,0.0007210989,0.002318693],"category_scores_gemma":[0.0003575984,0.0002562116,0.0006605127,0.0007700763,0.0003755171,0.0006721414,0.0007036106,0.00115904,0.001206504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004236371,"about_ca_system_score_gemma":0.0003696467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001553417,"about_ca_topic_score_gemma":0.003513081,"domain_scores_codex":[0.9996547,0.00001370105,0.00001340106,0.000158113,0.00009762916,0.00006256942],"domain_scores_gemma":[0.9997932,0.00005218085,0.00004049581,0.00002643751,0.00005407761,0.00003348006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001351946,0.00002165596,0.00665635,0.0002677616,0.00004639382,0.0001547719,0.0001669447,0.0002692696,0.9827158,0.0005993901,0.0009762177,0.007990194],"study_design_scores_gemma":[0.00005256234,0.0003486098,0.415351,0.0001934136,0.0003735176,0.002246691,0.001203367,0.01381657,0.464725,0.004270052,0.09722317,0.0001960106],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8695056,0.009365514,0.05165873,0.0009096467,0.0002823494,0.0001707467,0.05654179,0.002144289,0.009421235],"genre_scores_gemma":[0.8906413,0.00428833,0.03907897,0.001627173,0.0001160759,0.0003075519,0.05521536,0.001004055,0.007721346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002318693,"threshold_uncertainty_score":0.00775677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019570325572105,"score_gpt":0.2263956402872245,"score_spread":0.2161999370315035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}