{"id":"W4414829504","doi":"10.1111/pbi.70386","title":"Single Cell Multi‐Omics Reveals Rare Biosynthetic Cell Types in the Medicinal Tree <scp> <i>Camptotheca acuminata</i> </scp>","year":2025,"lang":"en","type":"article","venue":"Plant Biotechnology Journal","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus","funders":"Natural Sciences and Engineering Research Council of Canada; Genomics Center, University of Minnesota; University of Minnesota; University of California, Davis; Georgia Research Alliance; University of Georgia; National Science Foundation","keywords":"Camptothecin; Chromatin; Topoisomerase; Biosynthesis; Cell; Gene; Enzyme; Genomics; Cell type","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005990074,0.0002394852,0.0002522458,0.0002484605,0.0001983629,0.0000499468,0.0007509325,0.0005939774,0.000007215149],"category_scores_gemma":[0.00009652152,0.0001751091,0.0001129759,0.0002442075,0.0001698883,0.00000480868,0.0001348191,0.0007448031,0.000008982758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004432651,"about_ca_system_score_gemma":0.0001260489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008438437,"about_ca_topic_score_gemma":0.00007352842,"domain_scores_codex":[0.9985741,0.0001290881,0.0003530248,0.0003380879,0.0001464204,0.0004593059],"domain_scores_gemma":[0.999192,0.00008978754,0.0001906856,0.0004243896,0.00004719811,0.00005592428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003645794,0.0002248613,0.0001525689,0.00002418791,0.00003965698,0.00005402005,0.0001298507,0.000005903997,0.9898131,0.0003885482,0.002776507,0.006354344],"study_design_scores_gemma":[0.001066945,0.0003523074,0.00006744418,0.00005560067,0.00005849651,0.0004738411,0.0009523703,0.00006202605,0.8413568,0.0008235472,0.1546414,0.00008922478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680077,0.01417582,0.009256341,0.003965211,0.0009755388,0.0004186083,0.0001751828,0.00004276083,0.002982854],"genre_scores_gemma":[0.9914455,0.004252966,0.001136356,0.001676897,0.0001365777,0.00001291723,0.00004937354,0.00002340295,0.001266039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1518649,"threshold_uncertainty_score":0.7140741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019570325572105,"score_gpt":0.2263956402872245,"score_spread":0.2161999370315035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}