{"id":"W4414838029","doi":"10.1016/j.ijpharm.2025.126240","title":"A Thermostable nasal spray dried COVID vaccine candidate","year":2025,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Health Economics; University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Adjuvant; Aerosol; Trehalose; Spray drying; Particle size; Antigen; Nasal administration; Influenza vaccine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000149272,0.0002755401,0.0001928541,0.0001346862,0.0001052134,0.0001437101,0.0001458411,0.0002565765,0.001570821],"category_scores_gemma":[0.0000911928,0.0001025868,0.0002630647,0.00009633104,0.00008482867,0.0001465872,0.0001324384,0.0003102832,0.0005326503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002317912,"about_ca_system_score_gemma":0.0001899344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000388004,"about_ca_topic_score_gemma":0.000662021,"domain_scores_codex":[0.9999048,0.000008237593,0.000008305235,0.0000253431,0.00004028357,0.0000130029],"domain_scores_gemma":[0.9999545,0.000003899928,0.00001418047,0.000004737296,0.00001525448,0.000007436881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002295913,0.000007829842,0.00005029591,0.00002144218,0.000001846656,0.0000160361,0.000002543432,0.00002915007,0.9990317,0.00001618453,0.00003140098,0.0007686641],"study_design_scores_gemma":[0.00001260885,0.0004319621,0.001415663,0.000007400859,0.00001565283,0.0002771759,0.000008853277,0.0004950305,0.9931692,0.00001272288,0.004148757,0.000005024348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781408,0.001897505,0.01605397,0.0001115787,0.00008834489,0.0003338692,0.0008592395,0.0001755066,0.002339182],"genre_scores_gemma":[0.9686708,0.001238907,0.01876258,0.0001711454,0.00001722331,0.000234174,0.002141888,0.00004306664,0.008720219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001570821,"threshold_uncertainty_score":0.005254924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02398477891018845,"score_gpt":0.3893807527049788,"score_spread":0.3653959737947904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}