{"id":"W4414842391","doi":"10.1002/advs.202504474","title":"Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; Juravinski Cancer Centre","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Canadian Cancer Society","keywords":"Senescence; Priming (agriculture); T cell; Immune system; Cytotoxic T cell; Boosting (machine learning); Memory T cell; Blockade; Memory cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001394784,0.0002083024,0.0002113769,0.0001539023,0.00009345805,0.0001968555,0.00006436832,0.0002207865,0.001003844],"category_scores_gemma":[0.0001314466,0.0000801249,0.0001526156,0.00007819859,0.0001277347,0.0001366815,0.0001297714,0.000534675,0.0002362034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001155569,"about_ca_system_score_gemma":0.0001150437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008361037,"about_ca_topic_score_gemma":0.000111657,"domain_scores_codex":[0.9999298,0.00001487459,0.000008446192,0.00001093072,0.00001183215,0.00002408162],"domain_scores_gemma":[0.9999125,0.00001835539,0.00001970217,0.0000103898,0.000007854028,0.00003125185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003105181,0.00009025033,0.001031392,0.00004017224,0.00000512539,0.000104311,0.00002013056,0.00007412506,0.9953656,0.00006690263,0.00004994941,0.002841532],"study_design_scores_gemma":[0.0000675862,0.003394444,0.04856995,0.00002379977,0.00004272644,0.001572736,0.0001065336,0.002024696,0.9403107,0.0003334561,0.003546217,0.000007234981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977998,0.0009846773,0.0004500404,0.00003965734,0.00002036902,0.00001029907,0.00003624383,0.00003142987,0.0006274903],"genre_scores_gemma":[0.9989434,0.0002571035,0.0001899566,0.00003501601,0.000009697555,0.000008006844,0.0000578503,0.000004134171,0.0004948663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001003844,"threshold_uncertainty_score":0.003358126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00558193574953894,"score_gpt":0.2629512891800128,"score_spread":0.2573693534304739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}