{"id":"W4414844265","doi":"10.1093/gbe/evaf186","title":"Joint Effects of Balancing Selection and Population Bottlenecks on the Evolution of a Regulatory Region of Human Antiviral <i>APOBEC3</i>","year":2025,"lang":"en","type":"article","venue":"Genome Biology and Evolution","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; Research Organization of Information and Systems","keywords":"Haplogroup; Natural selection; Balancing selection; Selection (genetic algorithm); Population; Human evolutionary genetics; Biological dispersal; Negative selection; Haplotype; Selective sweep","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009347823,0.0003174259,0.0003995068,0.0002497568,0.0004630578,0.0005154902,0.0003861814,0.0004188061,0.0009336687],"category_scores_gemma":[0.002040035,0.0001861883,0.0004990594,0.0002154509,0.0005514089,0.0005267283,0.0004869268,0.0005460847,0.00009341376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005135975,"about_ca_system_score_gemma":0.0006798131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005042234,"about_ca_topic_score_gemma":0.004064081,"domain_scores_codex":[0.9998522,0.00006578479,0.000005571283,0.0000308126,0.00001656861,0.00002898386],"domain_scores_gemma":[0.999599,0.0002173336,0.00007104798,0.00002498437,0.00002825932,0.00005936898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.0006323954,0.0001419958,0.08696175,0.0001441241,0.0004330221,0.001030475,0.0004802937,0.8374009,0.04391856,0.01310054,0.000578632,0.01517739],"study_design_scores_gemma":[0.0001163769,0.0002652635,0.02625935,0.00001562863,0.0001281125,0.0001934982,0.0001416026,0.9648995,0.002325936,0.004962447,0.0006593859,0.00003283196],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953703,0.00009452219,0.003896818,0.0000593062,0.000007637559,0.000007019227,0.00003805277,0.00002783841,0.0004985321],"genre_scores_gemma":[0.9984941,0.00006745287,0.001164666,0.00001922869,0.000003462998,0.00001052442,0.0000558157,0.000008556416,0.0001760139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005042234,"threshold_uncertainty_score":0.01002574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005735397590714176,"score_gpt":0.2104225423111947,"score_spread":0.2046871447204805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}