{"id":"W4414845970","doi":"10.1038/s41398-025-03580-4","title":"The antioxidant N-acetylcysteine prevents cortical neuropathological phenotypes caused by adolescent Δ-9-tetrahydrocannabinol exposure in male rats","year":2025,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Neurochemical; Pathophysiology; Oxidative stress; Glutamate receptor; Prefrontal cortex; Antioxidant; Glutathione; Central nervous system; Neuroprotection","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003846164,0.0002112364,0.0002863176,0.0001181535,0.0002250849,0.00004339476,0.0001939888,0.0001480007,0.0001329953],"category_scores_gemma":[0.00005468252,0.0001488515,0.0001609882,0.0005006634,0.0002105683,0.00005476476,0.00002596781,0.0006641411,0.00001953887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005005797,"about_ca_system_score_gemma":0.0004847138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001209773,"about_ca_topic_score_gemma":0.00008136617,"domain_scores_codex":[0.9978279,0.0001989707,0.0005317563,0.00042127,0.0005633548,0.000456761],"domain_scores_gemma":[0.9993669,0.0000336069,0.00004917052,0.0003171348,0.00008674132,0.0001464946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003379627,0.004145621,0.6163499,0.000647535,0.0001594842,0.0001242843,0.0001809034,0.0001473834,0.09169894,0.01320831,0.2594756,0.01048243],"study_design_scores_gemma":[0.00414421,0.0004462583,0.9584852,0.0002335156,0.00006100455,0.00005068858,0.00009161577,0.0006427125,0.0007372844,0.0007395388,0.03416394,0.0002039945],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9208886,0.00528048,0.0004777013,0.06998158,0.0005669723,0.0009080993,0.00004367373,0.0000501886,0.001802682],"genre_scores_gemma":[0.9882365,0.0001667882,0.0001153401,0.001160754,0.000138862,0.0000821221,0.00004589056,0.00002104497,0.01003267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3421353,"threshold_uncertainty_score":0.6069989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01185443367467781,"score_gpt":0.2901824019035298,"score_spread":0.278327968228852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}