{"id":"W4414849082","doi":"10.1161/circgen.125.005198","title":"Digging Deeper Into Cardiovascular Plasma Proteomics: Opportunities and Limitations of Current Platforms","year":2025,"lang":"en","type":"review","venue":"Circulation Genomic and Precision Medicine","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre","funders":"","keywords":"Proteomics; Disease; Coronary artery disease; Biomarker discovery; Identification (biology); Biomarker; Risk assessment","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01809853,0.00129264,0.002426905,0.002808898,0.0009096581,0.006363764,0.002688282,0.00266852,0.00212144],"category_scores_gemma":[0.01397822,0.0008930868,0.001313899,0.002471668,0.002486007,0.007609225,0.003637338,0.004943783,0.001519327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001164697,"about_ca_system_score_gemma":0.00314991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001417687,"about_ca_topic_score_gemma":0.001494549,"domain_scores_codex":[0.9931786,0.002417332,0.0006178158,0.001090954,0.002370924,0.0003243749],"domain_scores_gemma":[0.9866747,0.007978087,0.0009483306,0.0008864621,0.003049852,0.0004624534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006122381,0.0001267544,0.007261219,0.029202,0.0009913783,0.0008536419,0.00119918,0.00169028,0.03589644,0.05332194,0.04119163,0.8276534],"study_design_scores_gemma":[0.00008015563,0.0006076422,0.01036208,0.00991136,0.0007354891,0.004744307,0.001605195,0.005116568,0.02111511,0.08198126,0.8633449,0.0003958914],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004721495,0.9394586,0.02890079,0.02019278,0.001622495,0.00005488693,0.00046536,0.0003253192,0.004258364],"genre_scores_gemma":[0.0407621,0.8834837,0.05881043,0.00942125,0.004670796,0.0002302445,0.0009564197,0.0001619047,0.001503245],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01809853,"threshold_uncertainty_score":0.09571528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1373879315558905,"score_gpt":0.3446697373332887,"score_spread":0.2072818057773982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}