{"id":"W4414867194","doi":"10.1016/j.cmet.2025.09.002","title":"The energy resistance principle","year":2025,"lang":"en","type":"review","venue":"Cell Metabolism","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute on Aging; National Institutes of Health; National Institute of Mental Health; Nathaniel Wharton Fund","keywords":"Bioenergetics; Work (physics); Energy (signal processing); Transformation (genetics); Energy transformation; Simple (philosophy); Property (philosophy); Resistance (ecology); Energy metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008992511,0.001015848,0.001290247,0.001467019,0.0004022635,0.002226935,0.001037812,0.001936397,0.007995623],"category_scores_gemma":[0.00111553,0.0002929999,0.0006280252,0.001303369,0.002101313,0.003303006,0.002066872,0.004372781,0.004113093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008933992,"about_ca_system_score_gemma":0.001325505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005276604,"about_ca_topic_score_gemma":0.0006255842,"domain_scores_codex":[0.9996451,0.0001157313,0.00002855633,0.00006105115,0.0001070031,0.00004252305],"domain_scores_gemma":[0.9996977,0.0001817892,0.00002762606,0.00001894463,0.00004806308,0.00002597923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001861737,0.00008007977,0.0001188876,0.009556721,0.0001326747,0.0003187869,0.0001918462,0.000382438,0.001704064,0.1535449,0.149492,0.6842914],"study_design_scores_gemma":[0.00001506259,0.00002779915,0.000104944,0.001524807,0.00002229657,0.0003399922,0.00003047083,0.00004519073,0.0001428668,0.02210868,0.9756295,0.000008397927],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001182826,0.9848078,0.0007643928,0.002929175,0.002489863,0.000005208067,0.00003040481,0.00001618353,0.00883866],"genre_scores_gemma":[0.003607157,0.9748716,0.0009598416,0.005716898,0.004489877,0.00002805186,0.00007896865,0.00001580602,0.01023184],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007995623,"threshold_uncertainty_score":0.02674806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392334372022086,"score_gpt":0.3238271165569733,"score_spread":0.2999037728367524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}