{"id":"W4414867194","doi":"10.1016/j.cmet.2025.09.002","title":"The energy resistance principle","year":2025,"lang":"en","type":"review","venue":"Cell Metabolism","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute on Aging; National Institutes of Health; National Institute of Mental Health; Nathaniel Wharton Fund","keywords":"Bioenergetics; Work (physics); Energy (signal processing); Transformation (genetics); Energy transformation; Simple (philosophy); Property (philosophy); Resistance (ecology); Energy metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004186588,0.0006268161,0.00269995,0.0002179491,0.0003290721,0.00006362429,0.0005933388,0.0004626944,0.00008715118],"category_scores_gemma":[0.0002477832,0.0003667595,0.0009837393,0.0007213313,0.0001458491,0.00004580039,0.0002197764,0.0006434534,0.0002208232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000543706,"about_ca_system_score_gemma":0.001183078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001267057,"about_ca_topic_score_gemma":0.00001272331,"domain_scores_codex":[0.9971868,0.0002639497,0.0008580437,0.000642496,0.0004252228,0.0006235088],"domain_scores_gemma":[0.9970844,0.0004586528,0.0004189909,0.001642888,0.0001461386,0.0002488866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001447242,0.00005083483,7.429202e-8,0.01109555,0.0002233103,0.00004889453,0.00001866128,1.537225e-8,0.000002302581,0.03978735,0.02656681,0.9221917],"study_design_scores_gemma":[0.0003550479,0.000006286144,0.000003489331,0.005047999,0.005365326,0.00001932289,0.00000511712,1.556014e-7,0.00005277099,0.000257752,0.9885752,0.0003115055],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[2.413715e-7,0.9104813,0.00007193459,0.00009020911,0.001997781,0.0007086397,0.00003144456,0.0001007641,0.08651774],"genre_scores_gemma":[4.148785e-7,0.6188828,0.0002664329,0.0001921749,0.0009647441,0.0002020032,0.00006344047,0.00005916259,0.3793688],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9620084,"threshold_uncertainty_score":0.9998784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392334372022086,"score_gpt":0.3238271165569733,"score_spread":0.2999037728367524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}