{"id":"W4414869167","doi":"10.1007/s11095-025-03920-5","title":"Metabolic Insights into Drug Absorption: Unveiling Piperine's Transformative Bioenhancing Potential","year":2025,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Piperaceae Chemical and Biological Studies","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Piperine; Bioavailability; Drug; Pharmacokinetics; Efflux; Prodrug; Drug metabolism; Intestinal permeability","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015524,0.0004623682,0.0001779686,0.0001661164,0.0001343143,0.0003196357,0.000215183,0.0003828185,0.002977107],"category_scores_gemma":[0.0001953792,0.0001336079,0.0002605864,0.0001619326,0.0002412544,0.0009909458,0.0002240839,0.0007346023,0.0002654395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002021844,"about_ca_system_score_gemma":0.0002080604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002881698,"about_ca_topic_score_gemma":0.0004721311,"domain_scores_codex":[0.9999665,0.000007356274,0.000001521758,0.00000894125,0.000006525949,0.000009065059],"domain_scores_gemma":[0.9999239,0.00002351556,0.0000232447,0.000007784767,0.00001019121,0.00001137221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005762196,0.00009309363,0.0005369954,0.0003823535,0.00001989961,0.0003170471,0.00008362649,0.0006113302,0.9633976,0.002916523,0.000182745,0.03088269],"study_design_scores_gemma":[0.00005621362,0.001979876,0.005735465,0.00005668358,0.00007803416,0.00071615,0.0001577973,0.004526028,0.9707343,0.002959651,0.01297183,0.0000280328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9160509,0.02331188,0.03830943,0.003250464,0.0002375975,0.000113982,0.0007540468,0.0002891378,0.0176826],"genre_scores_gemma":[0.9843758,0.006121983,0.006735379,0.0002789331,0.00005743882,0.0000142402,0.0001596235,0.00002337789,0.00223323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002977107,"threshold_uncertainty_score":0.0099594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2138467517681159,"score_gpt":0.5362313292573191,"score_spread":0.3223845774892032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}