{"id":"W4414873918","doi":"10.1093/brain/awaf375","title":"Reference proteins to improve Core 1 and Core 2 Alzheimer’s disease CSF and plasma biomarkers","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Université de Montréal; Centres Intégré Universitaires de Santé et de Services Sociaux; Institut Universitaire de Gériatrie de Montréal; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; Avid Radiopharmaceuticals; Genentech; Parkinsonfonden; Fondation pour la Recherche sur Alzheimer; Julius Clinical; Skånes universitetssjukhus; Novo Nordisk; Knut och Alice Wallenbergs Stiftelse; Vetenskapsrådet; Eisai; EU Joint Programme – Neurodegenerative Disease Research; Hjärnfonden; European Commission; Fondation Brain Canada; GHR Foundation; Alzheimerfonden; Alzheimer's Drug Discovery Foundation; Weston Brain Institute; Science for Life Laboratory; Cerveau Technologies; Cure Alzheimer's Fund; Teva Pharmaceutical Industries; Life Sciences, University of California, Los Angeles; Biogen; Eli Lilly and Company; Consortium canadien en neurodégénérescence associée au vieillissement; Bristol-Myers Squibb; Lunds Universitet; Siemens Healthineers; Amgen; Canadian Institutes of Health Research; Foundation for Barnes-Jewish Hospital; Prothena; Alexion Pharmaceuticals; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Parkinson's Foundation; Swedish Brain Power; Sanofi; National Institutes of Health; Mylan; Alzheimer's Association","keywords":"Biomarker; Cerebrospinal fluid; Concordance; Multiple sclerosis; Prospective cohort study; Dementia; Normalization (sociology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01009981,0.002284636,0.001677424,0.002186371,0.0007210521,0.002301458,0.001447693,0.001283306,0.00210816],"category_scores_gemma":[0.01865211,0.0006187332,0.001294181,0.002437197,0.0007716696,0.001080724,0.001510357,0.001069912,0.001573802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008579297,"about_ca_system_score_gemma":0.001296528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004154782,"about_ca_topic_score_gemma":0.004060533,"domain_scores_codex":[0.9937271,0.001675016,0.0006563691,0.00233093,0.00128226,0.0003283704],"domain_scores_gemma":[0.9942492,0.001250793,0.001178522,0.001361489,0.001803932,0.0001561336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007812757,0.0009604463,0.4644183,0.002281703,0.004177555,0.0008211615,0.001554109,0.01570029,0.1684867,0.004951898,0.01195271,0.3168823],"study_design_scores_gemma":[0.0005577394,0.00395035,0.7055771,0.0004785968,0.002394276,0.003333035,0.0004776425,0.04351626,0.167954,0.009012569,0.06243381,0.00031448],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7944666,0.01659776,0.1702377,0.0007519555,0.001174076,0.0006058054,0.008688568,0.002201744,0.005275746],"genre_scores_gemma":[0.8593094,0.002582295,0.1197449,0.0007359769,0.0002991681,0.001150042,0.01127277,0.0005985408,0.004306952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01009981,"threshold_uncertainty_score":0.05341357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04258308309500729,"score_gpt":0.3513372374439668,"score_spread":0.3087541543489595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}