{"id":"W4414874950","doi":"10.1101/2025.10.06.680650","title":"UBA1 Mutations Drive RIPK1-Mediated Cell Death and Monocyte Dysfunction in VEXAS Syndrome","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Otitis Media and Relapsing Polychondritis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Fondation pour la Recherche Médicale","keywords":"Efferocytosis; Inflammation; Monocyte; Myeloid; Proinflammatory cytokine; Chemokine; Haematopoiesis; Innate immune system; Cytokine; Macrophage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008902072,0.0003742317,0.0001527351,0.0002356655,0.0001565442,0.0001650983,0.0001151332,0.0002919969,0.001319737],"category_scores_gemma":[0.0001373321,0.0001118144,0.0002136273,0.000103464,0.0001932286,0.00008516667,0.000241657,0.000260829,0.0002228609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001236148,"about_ca_system_score_gemma":0.00005627295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002054942,"about_ca_topic_score_gemma":0.0002569327,"domain_scores_codex":[0.9999058,0.00002545742,0.00001521861,0.00002157409,0.00001822226,0.00001366919],"domain_scores_gemma":[0.99989,0.00002550868,0.0000400959,0.00000991724,0.000005920476,0.00002853928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001931799,0.00003956137,0.003111338,0.00003155828,0.00001368001,0.002724025,0.00003224676,0.0001186216,0.9922536,0.0001316525,0.00004704179,0.001303507],"study_design_scores_gemma":[0.00006451207,0.001035874,0.1026211,0.00003859333,0.00006194028,0.04993745,0.0002005392,0.003757302,0.8391782,0.0004184739,0.002664906,0.00002120638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986297,0.0001984997,0.0007877507,0.0000186359,0.000006450032,0.000007750667,0.0001337377,0.00001914283,0.0001983109],"genre_scores_gemma":[0.9991236,0.00009027878,0.0004568132,0.00001184789,0.00000277784,0.000006000351,0.00008074452,0.000004194869,0.0002238006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001319737,"threshold_uncertainty_score":0.004414976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062925684267826,"score_gpt":0.2246947624933819,"score_spread":0.2140655056507036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}