{"id":"W4414875944","doi":"10.1073/pnas.2528641123","title":"A secreted citrus protease cleaves an outer membrane protein of the Huanglongbing pathogen","year":2025,"lang":"en","type":"preprint","venue":"Proceedings of the National Academy of Sciences","topic":"Phytoplasmas and Hemiptera pathogens","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; HORIZON EUROPE European Research Council; National Natural Science Foundation of China; Gatsby Charitable Foundation; National Institute of Food and Agriculture; UK Research and Innovation; Citrus Research and Development Foundation; Hatch; U.S. Department of Agriculture","keywords":"Proteases; Protease; Bacterial outer membrane; Pathogen; Cysteine protease; Virulence; Secretion; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001352257,0.0002105948,0.000344225,0.00005274986,0.0003162223,0.00005492953,0.002216809,0.000265863,0.00003003025],"category_scores_gemma":[0.0004122117,0.00006866281,0.000282089,0.0008141628,0.000716628,0.0002353967,0.001057114,0.0004293651,3.05994e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003002277,"about_ca_system_score_gemma":0.00006114755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002683894,"about_ca_topic_score_gemma":0.000002377482,"domain_scores_codex":[0.9974108,0.00003470594,0.0005559677,0.0004868804,0.001285441,0.0002261523],"domain_scores_gemma":[0.9983473,0.00008572468,0.001053302,0.00001784741,0.0004428205,0.00005303961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002615555,0.00007194654,0.009380469,0.0002341455,0.00001976747,1.226045e-8,0.000205686,0.00003955104,0.9842953,0.004430797,0.00004624619,0.001249915],"study_design_scores_gemma":[0.0001022331,0.00008045202,0.1032284,0.0009604016,0.0000347436,0.000003748006,0.0002276531,0.0007169441,0.856332,0.03786024,0.0002611188,0.0001919833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927647,0.00008558208,8.273332e-8,0.002739794,0.00004348529,0.0009891666,0.0005262801,0.00001706535,0.002833812],"genre_scores_gemma":[0.9987268,0.00001282265,0.0005591489,0.0001860106,0.0001605315,0.00007478762,0.000001955762,9.740575e-7,0.000276965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1279633,"threshold_uncertainty_score":0.4119419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04861534725882519,"score_gpt":0.2751796229016806,"score_spread":0.2265642756428554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}