{"id":"W4414876132","doi":"10.1016/j.jbc.2025.110794","title":"Structural insights into hormone recognition and G-protein coupling of the urotensin-II receptor","year":2025,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Youth Innovation Promotion Association; Youth Innovation Promotion Association of the Chinese Academy of Sciences; China Academy of Space Technology; Science and Technology Commission of Shanghai Municipality; Shanghai Lingjun Program; Chinese Academy of Sciences; National Natural Science Foundation of China; National Key Research and Development Program of China; Canadian Anesthesiologists' Society; China Association for Science and Technology","keywords":"Receptor; G protein-coupled receptor; Transmembrane protein; Agonist; Transmembrane domain; Somatostatin receptor; Peptide; Signal transduction; Ligand (biochemistry)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002046568,0.00009619187,0.0003275089,0.00003221008,0.0000916749,0.0000101318,0.0001051288,0.0001176141,0.00004774137],"category_scores_gemma":[0.0009395863,0.00004924425,0.0002155103,0.000166974,0.0002840736,0.00003100868,0.0001375926,0.0004520009,6.844905e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003859192,"about_ca_system_score_gemma":0.00007123322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005309847,"about_ca_topic_score_gemma":2.234361e-7,"domain_scores_codex":[0.9991724,0.00003508358,0.0003251366,0.0001304167,0.0002300212,0.0001069462],"domain_scores_gemma":[0.9991556,0.00006915577,0.0001634113,0.0001390717,0.0003980173,0.00007467801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004279796,0.00002567546,0.0009603522,0.00008943155,0.0001172113,0.00001698715,0.00003391493,0.000002332143,0.9940337,0.000001768911,0.0001874609,0.004103194],"study_design_scores_gemma":[0.001110037,0.0002573417,0.02945044,0.000375107,0.00005445789,0.00009483664,0.0001373602,0.0000338991,0.9665259,0.000527877,0.00137114,0.00006165676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946139,0.00437926,0.00001788743,0.0003595298,0.00004507464,0.0001170733,0.000003619353,0.000004462566,0.0004592169],"genre_scores_gemma":[0.9984643,0.0009133694,0.0002087857,0.00005434851,0.0001657358,0.000001349603,0.00000509235,0.000003878572,0.0001831757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02849009,"threshold_uncertainty_score":0.2008122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03930345265554286,"score_gpt":0.2806586984360925,"score_spread":0.2413552457805497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}