{"id":"W4414887720","doi":"10.1080/21645515.2025.2567703","title":"PV-10 enhances immune responses in hepatitis B vaccination through STING pathway","year":2025,"lang":"en","type":"article","venue":"Human Vaccines & Immunotherapeutics","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Alberta Children's Hospital Foundation; Children's Hospital Foundation","keywords":"Sting; Immune system; HBsAg; Chemokine; Hepatitis B; Adjuvant; Cytokine; Antigen; Hepatitis B virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001116551,0.000260215,0.0001559029,0.0001183538,0.00005863318,0.0001451597,0.000118135,0.0002260586,0.001226507],"category_scores_gemma":[0.00007799402,0.00009566436,0.0001898003,0.00005534598,0.0001302287,0.0001479166,0.0001295374,0.0005811941,0.0002364639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001292743,"about_ca_system_score_gemma":0.0001135437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002526211,"about_ca_topic_score_gemma":0.0004494926,"domain_scores_codex":[0.9999083,0.0000291427,0.000004752563,0.000009044023,0.00001678572,0.00003186312],"domain_scores_gemma":[0.9999568,0.000009161388,0.00001102052,0.000003376412,0.000004492462,0.00001510823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002620164,0.0001135529,0.0001472786,0.00005285596,0.000003970352,0.00002517874,0.0000102585,0.00009949546,0.9977484,0.0000220231,0.00003090002,0.001484037],"study_design_scores_gemma":[0.00005115375,0.00297942,0.002995309,0.00001006731,0.00002018014,0.0001451898,0.00002513307,0.001338975,0.9909259,0.00003639965,0.00146811,0.00000410658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997074,0.001347614,0.0005974267,0.00006083608,0.00002968263,0.00002294068,0.0000521177,0.00003548338,0.0007797979],"genre_scores_gemma":[0.997546,0.0006975834,0.0006251269,0.00005916743,0.000009084762,0.00001513005,0.0001104927,0.000004829443,0.0009325172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001226507,"threshold_uncertainty_score":0.004103124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02255753530461743,"score_gpt":0.309775901581242,"score_spread":0.2872183662766246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}