{"id":"W4414899992","doi":"10.1126/scisignal.adx3087","title":"Phosphorylation of RYR1 at Ser <sup>2902</sup> decreases Ca <sup>2+</sup> leak in skeletal muscle and susceptibility to malignant hyperthermia and heat stroke","year":2025,"lang":"en","type":"article","venue":"Science Signaling","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Human Genome Research Institute; National Institutes of Health","keywords":"RYR1; Malignant hyperthermia; Skeletal muscle; Ryanodine receptor; Phosphorylation; Endoplasmic reticulum; Point mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001729128,0.0004708998,0.0004151784,0.0001695214,0.0001048067,0.0002194048,0.0002123139,0.0003097337,0.001827715],"category_scores_gemma":[0.0002058227,0.0002493716,0.0003146959,0.00009437636,0.0002814023,0.0001965706,0.0002027405,0.000504123,0.0004642259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001504103,"about_ca_system_score_gemma":0.0001167974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002880116,"about_ca_topic_score_gemma":0.0003793475,"domain_scores_codex":[0.9998608,0.00002851997,0.00002393029,0.00003140146,0.000024031,0.00003128491],"domain_scores_gemma":[0.9998187,0.00001676364,0.00008131429,0.00001347035,0.000009610646,0.00006009954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005209495,0.00005988308,0.0003303545,0.00003206772,0.00001166169,0.00004161467,0.000006794627,0.00007930904,0.9980645,0.00003608721,0.00006119762,0.0007556271],"study_design_scores_gemma":[0.0001655262,0.001656522,0.02425604,0.00001201978,0.00005172086,0.0008244962,0.00005176261,0.00208545,0.9692819,0.00007229461,0.001529621,0.00001257383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997598,0.0006077713,0.0008401597,0.0001084488,0.00002794569,0.00001766914,0.0002010371,0.00005212684,0.0005469192],"genre_scores_gemma":[0.9962574,0.0005129136,0.001152058,0.0001163375,0.0000156382,0.00004134153,0.0004431593,0.00002957452,0.001431531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001827715,"threshold_uncertainty_score":0.006114304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009066580588922046,"score_gpt":0.2450289673703612,"score_spread":0.2359623867814392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}