{"id":"W4414901463","doi":"10.1371/journal.pgen.1011848","title":"Immunophenotypic changes in the tumor and tumor microenvironment during progression to multiple myeloma","year":2025,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Janssen Pharmaceuticals; Janssen Research and Development; Vlaamse regering; European Commission; Agentschap Innoveren en Ondernemen; Multiple Myeloma Research Foundation","keywords":"Monoclonal gammopathy of undetermined significance; Tumor microenvironment; Multiple myeloma; CD8; Immune system; Bone marrow; Population; Pathogenesis; Plasma cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001754658,0.0001081143,0.0001515525,0.0008297125,0.0001622236,0.0002359571,0.00009908799,0.0002055289,0.0005860329],"category_scores_gemma":[0.0002243597,0.0001172959,0.00009385368,0.0003428027,0.0001325855,0.0001251044,0.0001565625,0.0001569413,0.0001470929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001308236,"about_ca_system_score_gemma":0.0000872344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001027437,"about_ca_topic_score_gemma":0.0008296947,"domain_scores_codex":[0.9999198,0.00001486097,0.000004621329,0.00002183716,0.00001938421,0.00001943784],"domain_scores_gemma":[0.999868,0.00002764927,0.00003808449,0.000008860901,0.00002790145,0.00002936779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0016594,0.00004195334,0.4068771,0.00006305159,0.00004620649,0.00138744,0.0004288285,0.0002315971,0.5741932,0.0001013976,0.0001350028,0.01483471],"study_design_scores_gemma":[0.00000715452,0.0002612747,0.976223,0.000003733478,0.00002680819,0.001874382,0.000249746,0.0004443245,0.02013014,0.00007878478,0.0006949547,0.000005633612],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985864,0.0005310201,0.0003539038,0.000008430012,0.000001718117,0.000007557298,0.0001433747,0.0000129357,0.0003547518],"genre_scores_gemma":[0.998906,0.0002403758,0.0003582668,0.00001301407,0.000005424338,0.000009356699,0.0001927411,0.000002816575,0.0002720032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001027437,"threshold_uncertainty_score":0.002042949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751963074377012,"score_gpt":0.284325659607385,"score_spread":0.2668060288636149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}