{"id":"W4414901463","doi":"10.1371/journal.pgen.1011848","title":"Immunophenotypic changes in the tumor and tumor microenvironment during progression to multiple myeloma","year":2025,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Janssen Pharmaceuticals; Janssen Research and Development; Vlaamse regering; European Commission; Agentschap Innoveren en Ondernemen; Multiple Myeloma Research Foundation","keywords":"Monoclonal gammopathy of undetermined significance; Tumor microenvironment; Multiple myeloma; CD8; Immune system; Bone marrow; Population; Pathogenesis; Plasma cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008563007,0.0001390902,0.0001747808,0.0001371118,0.00009701933,0.00002735869,0.0001153247,0.00002576333,0.00002121853],"category_scores_gemma":[0.00008377496,0.00009281018,0.00002256208,0.0001703863,0.0000528971,0.00001172577,0.0001576062,0.0001335819,0.00002984405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008651567,"about_ca_system_score_gemma":0.00002996044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009881645,"about_ca_topic_score_gemma":0.00008936789,"domain_scores_codex":[0.9989646,0.00005939345,0.0001467602,0.0002535801,0.0002518073,0.0003238718],"domain_scores_gemma":[0.9994706,0.00006600791,0.00002590786,0.000320752,0.00001813178,0.00009861745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000549484,0.0006193051,0.5690353,0.0002895642,0.0000796332,0.0002790822,0.0006511934,0.00000400331,0.4169925,0.000005970007,0.00006429127,0.01142968],"study_design_scores_gemma":[0.001919898,0.000264802,0.7143468,0.0002711707,0.00003456214,0.00002009877,0.0001855835,0.0004892573,0.2817026,0.00001233218,0.0006825621,0.00007037688],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942383,0.002049924,0.000003510118,0.002152105,0.00002696441,0.001346349,0.00001097699,0.00001613688,0.0001557939],"genre_scores_gemma":[0.9973433,0.0001728776,0.001458971,0.0005453688,0.00003928729,0.0002183059,0.00001151626,0.00001463039,0.0001957686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1453115,"threshold_uncertainty_score":0.3784689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751963074377012,"score_gpt":0.284325659607385,"score_spread":0.2668060288636149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}