{"id":"W4414903164","doi":"10.2196/81293","title":"Effectiveness, Engagement, and Safety of a Digital Therapeutic (CT-155/BI 3972080) for Treating Negative Symptoms in People With Schizophrenia: Protocol for the Phase 3 CONVOKE Randomized Controlled Trial","year":2025,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Digital Mental Health Interventions","field":"Psychology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Randomized controlled trial; Protocol (science); Digital health; Intention-to-treat analysis; Randomization; Phase (matter); Intervention (counseling)","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01947879,0.005137132,0.007012091,0.001742531,0.002643167,0.003500999,0.00283014,0.004808475,0.05854172],"category_scores_gemma":[0.01676263,0.002462546,0.004754875,0.001853658,0.003134286,0.003457563,0.001516235,0.006907553,0.008816562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004181293,"about_ca_system_score_gemma":0.01290184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002770155,"about_ca_topic_score_gemma":0.006159851,"domain_scores_codex":[0.9905668,0.005225431,0.001042886,0.0009895081,0.001062344,0.001113094],"domain_scores_gemma":[0.9927149,0.001653014,0.001807142,0.0008343149,0.001700012,0.001290611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9308407,0.01580928,0.0007186262,0.01146615,0.001401299,0.0001588613,0.0003574705,0.001214755,0.001933602,0.001918279,0.01084487,0.02333615],"study_design_scores_gemma":[0.9548515,0.02545953,0.001521569,0.001419293,0.0007561222,0.00004008946,0.0001238128,0.0008550599,0.0005480775,0.001246771,0.01310208,0.00007612062],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.003622128,0.0002578805,0.0006830013,0.0001490626,0.0001838388,0.9932542,0.001052776,0.00005852603,0.0007386357],"genre_scores_gemma":[0.004485328,0.0001669442,0.001288881,0.0001590735,0.00004617755,0.9932368,0.0001908425,0.000005750296,0.0004201461],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.05854172,"threshold_uncertainty_score":0.1958416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1165220046762261,"score_gpt":0.5585758145972418,"score_spread":0.4420538099210157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}