{"id":"W4414907871","doi":"10.1021/acsinfecdis.5c00515","title":"Benzodeazaoxaflavin Sirtuin Inhibitors Inhibit <i>Schistosoma mansoni</i> Sirt2 and Cause Phenotypic Changes and Lethality in Schistosomula and Adult Worm Stages","year":2025,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; European Regional Development Fund; Université de Fribourg; Consiglio Nazionale delle Ricerche; H2020 European Research Council; Centre National de la Recherche Scientifique; Sapienza Università di Roma; Ministero dell'Università e della Ricerca; Institut National de la Santé et de la Recherche Médicale; Université de Strasbourg; Albert-Ludwigs-Universität Freiburg; Università degli Studi Roma Tre; Lazio Innova; Associazione Italiana per la Ricerca sul Cancro; Deutsche Forschungsgemeinschaft; Universität Basel","keywords":"SIRT2; Sirtuin; Lethality; Phenotype; Epigenetics; Cytotoxicity; Disease; Histone; Drug","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006664143,0.0002369222,0.0001407494,0.0001786446,0.000101459,0.0001082776,0.0001043769,0.0001429064,0.0025717],"category_scores_gemma":[0.0000610383,0.0000688166,0.0001508911,0.0001020726,0.00008791147,0.00009669532,0.00008776783,0.0002732492,0.0002805553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001220095,"about_ca_system_score_gemma":0.00009961796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006468879,"about_ca_topic_score_gemma":0.001909253,"domain_scores_codex":[0.9999567,0.00000956539,0.000003227348,0.000006957755,0.00001264028,0.00001085355],"domain_scores_gemma":[0.9999732,0.000003619326,0.00001046792,0.000002650896,0.000004402231,0.000005659946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002085695,0.00003911222,0.0003204091,0.0000815513,0.00001100099,0.0000314354,0.000006315059,0.00007678598,0.9921639,0.00005594237,0.0001773177,0.006827657],"study_design_scores_gemma":[0.0000559976,0.001108542,0.008804779,0.000008900299,0.00002794135,0.0001655299,0.0000177674,0.0006157372,0.9815316,0.00003469322,0.00762283,0.000005518448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842734,0.0065134,0.002805694,0.0002881573,0.00007266413,0.00007790119,0.000821901,0.0002237619,0.004923132],"genre_scores_gemma":[0.9885126,0.003224574,0.002582359,0.0001145465,0.00001583455,0.00003305486,0.0007342699,0.00001463056,0.004768108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0025717,"threshold_uncertainty_score":0.008603215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006365611844387964,"score_gpt":0.2592925122271743,"score_spread":0.2529269003827863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}