{"id":"W4414907871","doi":"10.1021/acsinfecdis.5c00515","title":"Benzodeazaoxaflavin Sirtuin Inhibitors Inhibit <i>Schistosoma mansoni</i> Sirt2 and Cause Phenotypic Changes and Lethality in Schistosomula and Adult Worm Stages","year":2025,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; European Regional Development Fund; Université de Fribourg; Consiglio Nazionale delle Ricerche; H2020 European Research Council; Centre National de la Recherche Scientifique; Sapienza Università di Roma; Ministero dell'Università e della Ricerca; Institut National de la Santé et de la Recherche Médicale; Université de Strasbourg; Albert-Ludwigs-Universität Freiburg; Università degli Studi Roma Tre; Lazio Innova; Associazione Italiana per la Ricerca sul Cancro; Deutsche Forschungsgemeinschaft; Universität Basel","keywords":"SIRT2; Sirtuin; Lethality; Phenotype; Epigenetics; Cytotoxicity; Disease; Histone; Drug","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008317026,0.0002882075,0.0003692278,0.0003274406,0.0003871727,0.00006932994,0.0000745049,0.0002161916,0.00003879622],"category_scores_gemma":[0.0002243729,0.0002850407,0.00004262047,0.0002153076,0.0004357003,0.000204096,0.0001745977,0.0003678993,0.00001353479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008440572,"about_ca_system_score_gemma":0.00005499143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001493018,"about_ca_topic_score_gemma":0.007366963,"domain_scores_codex":[0.9986682,0.0001576972,0.0002838319,0.0005059579,0.00003833448,0.0003459972],"domain_scores_gemma":[0.9992121,0.0003101532,0.0001030353,0.0002411264,0.00006682735,0.0000667495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001879328,0.0004149055,0.9445056,0.0001763268,0.0002058629,0.00002077519,0.0006864757,0.000003431921,0.0311854,0.005711901,0.001980124,0.01492128],"study_design_scores_gemma":[0.004190391,0.0003852464,0.9518365,0.000462309,0.0004214811,0.0001316389,0.0006780559,0.000008797487,0.01586497,0.003377164,0.02190194,0.0007414561],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768525,0.02017735,0.00001088992,0.0008051131,0.0003722307,0.0003224817,0.0001670801,0.0001243294,0.001168039],"genre_scores_gemma":[0.9952369,0.002488231,0.000008844667,0.0007462412,0.00003649755,0.00007307121,0.00006820164,0.00001788431,0.00132414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01992182,"threshold_uncertainty_score":0.9999602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006365611844387964,"score_gpt":0.2592925122271743,"score_spread":0.2529269003827863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}