{"id":"W4414913305","doi":"10.3390/biomedicines13102442","title":"Cyclophilin Inhibitor Rencofilstat Combined with Proteasome Inhibitor Ixazomib Increases Proteotoxic Cell Death in Advanced Prostate Cancer Cells with Minimal Effects on Non-Cancer Cells","year":2025,"lang":"en","type":"article","venue":"Biomedicines","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"National Cancer Institute; Geriatric Research Education and Clinical Center; NIH Clinical Center; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"Ixazomib; Prostate cancer; Proteasome inhibitor; Programmed cell death; Cancer cell; Syngenic; Apoptosis; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005324455,0.0002815204,0.0002683915,0.0001862234,0.00009550758,0.000158996,0.0001107945,0.0001207579,0.001684561],"category_scores_gemma":[0.00003616993,0.00007976469,0.0001971735,0.0001549245,0.0001045393,0.00009079599,0.00008997469,0.0004200111,0.000212738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002190873,"about_ca_system_score_gemma":0.0002588935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001142327,"about_ca_topic_score_gemma":0.002245515,"domain_scores_codex":[0.999935,0.000006004445,0.000004892793,0.0000130779,0.00002063955,0.00002040862],"domain_scores_gemma":[0.9999613,0.00000433596,0.000009959918,0.000003664461,0.000005773403,0.00001499999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005152085,0.0001127276,0.0003246831,0.000118281,0.00001735652,0.00004720961,0.00001379592,0.0001626413,0.9953793,0.00005612073,0.0002460267,0.003006694],"study_design_scores_gemma":[0.00005469116,0.001335366,0.005955667,0.000008109363,0.00003852943,0.000178588,0.00002239253,0.0005990826,0.9878984,0.00001673285,0.003887711,0.000004731981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915379,0.004405832,0.0009645779,0.0001413917,0.00007517941,0.00004229677,0.0005933042,0.0001630027,0.002076516],"genre_scores_gemma":[0.9927087,0.002595564,0.001050393,0.00005287139,0.00001711259,0.00003738824,0.0007251871,0.00001243651,0.002800271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001684561,"threshold_uncertainty_score":0.005635381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004092825607968657,"score_gpt":0.2400514327997586,"score_spread":0.23595860719179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}