{"id":"W4414919583","doi":"10.1016/j.mcpro.2025.101083","title":"Whole Blood Proteome Dynamics Defines Predictive Diagnostic and Prognostic Signatures of Cryptococcal Infection","year":2025,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thermo Fisher Scientific (Canada); University of Guelph","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Cryptococcus neoformans; Proteome; Immune system; Cryptococcosis; Proteomics; Cryptococcus; Pathogen; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003728454,0.0004102845,0.0003787144,0.0007247764,0.0001718715,0.0007813221,0.000136033,0.0005445791,0.0005996847],"category_scores_gemma":[0.0004916354,0.0001580189,0.0001731067,0.0004949864,0.0002479359,0.0003616821,0.0003074284,0.0005279573,0.0002329774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002349496,"about_ca_system_score_gemma":0.0001922917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004910736,"about_ca_topic_score_gemma":0.0004613958,"domain_scores_codex":[0.9998227,0.00002274255,0.00001036613,0.00006642366,0.00004067629,0.00003712831],"domain_scores_gemma":[0.9998084,0.00003213359,0.00007102086,0.00001485034,0.0000339996,0.00003969391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001511206,0.0001168629,0.08683778,0.0001736836,0.00008549303,0.0003404913,0.0001502664,0.0007127094,0.8915341,0.0002088013,0.0006415317,0.01768706],"study_design_scores_gemma":[0.00002712253,0.0007684167,0.7297207,0.00007237706,0.0002049443,0.002267192,0.0003878552,0.01755491,0.2442685,0.0009461012,0.003722068,0.00005969886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912998,0.002106306,0.004425134,0.0001158726,0.0000289219,0.00002654636,0.001138491,0.0000862897,0.0007726293],"genre_scores_gemma":[0.9943083,0.001077424,0.003205792,0.0001002799,0.00002767484,0.00002305023,0.0008550974,0.00001388511,0.000388636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007813221,"threshold_uncertainty_score":0.002006114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00417082832102181,"score_gpt":0.2248279275538393,"score_spread":0.2206570992328175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}