{"id":"W4414919793","doi":"10.1101/2025.10.05.680573","title":"High-Resolution Characterization of rAAV Genomes for Vector Quality Using Long-Read Sequencing","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Genome; Plasmid; Capsid; DNA sequencing; DNA; Residual; Gene; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002341836,0.000642129,0.0005445368,0.001434557,0.0004119698,0.001224632,0.0005592129,0.0005671589,0.001481095],"category_scores_gemma":[0.003605183,0.0002806307,0.0007144834,0.001286188,0.0003622712,0.0007243942,0.0005428318,0.0007104939,0.001171415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006445451,"about_ca_system_score_gemma":0.0005546652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001922518,"about_ca_topic_score_gemma":0.002167172,"domain_scores_codex":[0.9982492,0.0002320458,0.000168878,0.0005390138,0.0006907231,0.000120198],"domain_scores_gemma":[0.9974961,0.0006693621,0.0004950432,0.0003332875,0.0009023462,0.0001038953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006784936,0.0001164485,0.02784033,0.0005645423,0.0001632586,0.0001707429,0.0003066221,0.007885654,0.908394,0.00136475,0.002207685,0.05030742],"study_design_scores_gemma":[0.00001742371,0.0002043234,0.03795681,0.0000547453,0.0001269506,0.0002670915,0.0001344578,0.06191756,0.8864796,0.001426636,0.01133354,0.00008087113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7331221,0.001818877,0.2256222,0.0002629733,0.00009077261,0.0001579828,0.02781808,0.008037941,0.003069097],"genre_scores_gemma":[0.7171826,0.0007761661,0.2210848,0.0002396187,0.00003044098,0.0002590659,0.05626465,0.00170864,0.002453915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002341836,"threshold_uncertainty_score":0.01238495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05821146206617186,"score_gpt":0.319277292959075,"score_spread":0.2610658308929032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}