{"id":"W4414922234","doi":"10.1002/alz.70695","title":"White matter hyperintensities precede other biomarkers in <i>GRN</i> frontotemporal dementia","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; Occupational Cancer Research Centre; London Health Sciences Centre; Western University; Douglas Mental Health University Institute; Université Laval; University of Toronto; Montreal Neurological Institute and Hospital","funders":"Medical Research Council; Canadian Institutes of Health Research; National Institute for Health and Care Research; NIHR Cambridge Biomedical Research Centre; Wellcome Trust; Weston Brain Institute; Fonds de Recherche du Québec - Santé; Department of Health and Social Care","keywords":"Hyperintensity; Frontotemporal dementia; Dementia; White matter; Disease; Leukoaraiosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001517023,0.0009271513,0.0007020587,0.0008449362,0.000802636,0.001007718,0.0007765679,0.0006928351,0.004297216],"category_scores_gemma":[0.003007654,0.0002794213,0.0009635607,0.0009232796,0.0003988947,0.0005817927,0.0008477261,0.0007366601,0.0006523597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007058803,"about_ca_system_score_gemma":0.0004531522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01475381,"about_ca_topic_score_gemma":0.02327256,"domain_scores_codex":[0.9994893,0.00008396547,0.00005072928,0.0002583641,0.00006664245,0.00005092744],"domain_scores_gemma":[0.9982548,0.000267378,0.0009262591,0.0001822349,0.0002034131,0.0001658455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001207837,0.00005281937,0.9870407,0.0001244967,0.0005305585,0.0006024513,0.0001887556,0.000298416,0.001993125,0.0001480972,0.001441456,0.006371354],"study_design_scores_gemma":[0.00001846478,0.00006833265,0.9978021,0.00003600812,0.0001367944,0.0005107257,0.00005569712,0.0002386648,0.0002241075,0.0003650275,0.0005372898,0.000006879332],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924178,0.0007914801,0.0003622484,0.0001859488,0.00002444208,0.00002201706,0.004953131,0.00003183564,0.001211114],"genre_scores_gemma":[0.9942876,0.0001760465,0.0005402399,0.000120325,0.00003149756,0.00002114508,0.004415202,0.00001272183,0.0003953111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01475381,"threshold_uncertainty_score":0.02933586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0257705897153389,"score_gpt":0.2905715037897318,"score_spread":0.2648009140743929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}