{"id":"W4414923017","doi":"10.1002/advs.202510309","title":"A Programmable, 3D Neuron‐On‐Chip Platform Integrating Near Real‐Time Biosensing and Multiaxial Loading for Mechanobiological Injury Profiling","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Microfluidics; Biosensor; Biomarker; Polydimethylsiloxane; Biochip; Neuroprotection; Microelectromechanical systems; Structural integrity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005630411,0.0002887858,0.0002701574,0.0002901785,0.001154796,0.0003769336,0.0005418863,0.0000657592,0.00000106089],"category_scores_gemma":[0.003863451,0.0002329035,0.00006062972,0.001712437,0.0008898763,0.0009919439,0.0002708171,0.0003211672,0.000005795363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007684848,"about_ca_system_score_gemma":0.0001344789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003820471,"about_ca_topic_score_gemma":7.157872e-7,"domain_scores_codex":[0.9971597,0.00003305195,0.0003391033,0.001234848,0.0003298836,0.0009034229],"domain_scores_gemma":[0.998671,0.0006774709,0.0001175288,0.0003078489,0.00006493443,0.0001612255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007884295,0.00002241089,0.00001995466,0.00001910367,4.695674e-7,0.000007804058,0.00004806914,0.0004418478,0.9360313,0.006178296,0.00000190774,0.05715002],"study_design_scores_gemma":[0.0002911241,0.0004020686,0.00004271493,0.00009932389,0.000004041313,0.00001604296,0.00003298604,0.1854281,0.8125528,0.000616104,0.0002976422,0.0002170179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936765,0.000008994962,0.003313897,0.0001468478,0.0006990035,0.0009570812,0.00001015531,0.0003490088,0.0008385536],"genre_scores_gemma":[0.9671497,0.00002708617,0.0318417,0.0007094855,0.00003571317,0.00005735042,7.665307e-7,0.0000185179,0.0001597172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1849863,"threshold_uncertainty_score":0.9497531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02712102700790234,"score_gpt":0.3095303060747556,"score_spread":0.2824092790668532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}