{"id":"W4414924571","doi":"10.1101/2025.10.07.680938","title":"Aggregation-prone alpha-synuclein proteoforms and dysregulated molecular signatures in the vermiform appendix of synucleinopathy patients","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Intraperitoneal and Appendiceal Malignancies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders; Université de Sherbrooke","funders":"College of Engineering, Michigan State University; National Institutes of Health; Parkinson's UK; Michigan State University","keywords":"Vermiform; Appendix; Substantia nigra; Vagus nerve; Alpha-synuclein; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005373515,0.0005236551,0.0007835454,0.0003687252,0.0001208211,0.00007868319,0.0004305922,0.0005581849,0.00003685767],"category_scores_gemma":[0.0001823039,0.0003950289,0.0001493152,0.0006066058,0.0002472071,0.0001191726,0.0003679819,0.0008696483,0.00001025221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001344256,"about_ca_system_score_gemma":0.0003522812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001161296,"about_ca_topic_score_gemma":0.000003334344,"domain_scores_codex":[0.9973193,0.0001104685,0.0007378787,0.0007001646,0.0006253374,0.0005068681],"domain_scores_gemma":[0.9981053,0.00005554506,0.0004371715,0.0008582783,0.0004123678,0.0001313566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007280817,0.001892832,0.06010862,0.008580821,0.0006849913,0.0006290465,0.0003677279,0.0001209567,0.9159477,0.01032528,0.0004805868,0.0001333545],"study_design_scores_gemma":[0.002104254,0.0004057561,0.487544,0.003809742,0.0003362914,7.835661e-8,0.00002615571,0.0004662482,0.5038059,0.00002613216,0.0008367746,0.0006387087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950001,0.00126212,0.00002819709,0.0003241851,0.0002524991,0.002706645,0.0002646275,0.00009826099,0.00006334058],"genre_scores_gemma":[0.99818,0.0001112214,0.0009158329,0.0004094257,0.00006354939,0.0002545425,0.000004479279,0.00005305736,0.000007857018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4274354,"threshold_uncertainty_score":0.9998502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006200921418218731,"score_gpt":0.2107039921912761,"score_spread":0.2045030707730573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}