{"id":"W4414925391","doi":"10.3389/fimmu.2025.1675786","title":"Production of functional CD19 CAR T cells under hypoxic manufacturing conditions","year":2025,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Center for Innovative Medicine; National Cancer Institute; Vetenskapsrådet; Karolinska Institutet; Cancerfonden","keywords":"CD19; Phenotype; Hypoxia (environmental); Chimeric antigen receptor; T cell; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001641845,0.0003299646,0.0001987887,0.0001408224,0.0001253568,0.0002828942,0.0001804544,0.0002740044,0.002480695],"category_scores_gemma":[0.0001442082,0.0001138325,0.0001708995,0.00009319177,0.0001409766,0.0001266825,0.0003038647,0.000303357,0.0004626958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001312494,"about_ca_system_score_gemma":0.000125675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003189396,"about_ca_topic_score_gemma":0.0004397549,"domain_scores_codex":[0.9997867,0.0000453699,0.00001994267,0.00004052935,0.00004867986,0.00005893045],"domain_scores_gemma":[0.9998759,0.00002386451,0.00003067799,0.00002272386,0.00002039913,0.00002653093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007111454,0.00001686515,0.0002473559,0.00002100204,0.000002259645,0.00003850725,0.00002071969,0.00008159265,0.9985995,0.00003302882,0.00003557669,0.000832584],"study_design_scores_gemma":[0.00002814376,0.001078889,0.003300253,0.000006443539,0.00002383829,0.0004410257,0.00003761275,0.000800038,0.9901791,0.00003250707,0.004066369,0.000005894834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933167,0.000343524,0.004076477,0.00004121714,0.00001875586,0.00006875169,0.0003712413,0.00007331126,0.001690102],"genre_scores_gemma":[0.9910268,0.000229228,0.004712214,0.00004875676,0.00001668033,0.00009598345,0.0008283588,0.00002439974,0.003017567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002480695,"threshold_uncertainty_score":0.008298695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01606543709790039,"score_gpt":0.2731994918521396,"score_spread":0.2571340547542392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}