{"id":"W4414933038","doi":"10.1002/alz.70718","title":"Metabolic and vascular contributions to dementia: Soluble epoxide hydrolase‐derived linoleic acid oxylipins and glycemic status are related to cerebral small vessel disease markers, atrophy, and cognitive performance","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Sunnybrook Hospital; Health Sciences Centre; Occupational Cancer Research Centre; Toronto Western Hospital; Indoc Research; Sunnybrook Health Science Centre; Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"Banting and Best Diabetes Centre, University of Toronto; Ministry of Colleges and Universities; Temerty Family Foundation; University of Toronto; National Institute of Food and Agriculture; Queen's University; Canada Research Chairs; Government of Ontario; Canadian Institutes of Health Research; Centre for Addiction and Mental Health Foundation; Weston Brain Institute; Fondation Leducq; McMaster University; Eli Lilly and Company; BrightFocus Foundation; Faculty of Health Sciences, Queen's University; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Alzheimer's Association; University of Ottawa","keywords":"Metabolite; Epoxide; Linoleic acid; Disease; Metabolic pathway; Glycemic; Substrate (aquarium); Epoxide hydrolase 2; Lipoxygenase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008188316,0.0004859674,0.000295842,0.0004960806,0.0002533,0.000634285,0.0002981398,0.0004667384,0.002091877],"category_scores_gemma":[0.001486208,0.0002122681,0.0005236948,0.0008062745,0.0002344103,0.0002883369,0.0003927287,0.0005787506,0.000135899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000170277,"about_ca_system_score_gemma":0.0002963179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004418324,"about_ca_topic_score_gemma":0.00463081,"domain_scores_codex":[0.9998028,0.00005961781,0.00001903333,0.00005871177,0.00003189888,0.0000279354],"domain_scores_gemma":[0.9992297,0.0001366316,0.0004067374,0.00005379316,0.0000592378,0.000113914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001283942,0.0001271296,0.9919655,0.00005402782,0.0007914266,0.00006266111,0.00006526147,0.0001112694,0.001060352,0.00004235797,0.00007884215,0.00435723],"study_design_scores_gemma":[0.00001112489,0.0001115898,0.9990755,0.000009724862,0.0001994595,0.00008657836,0.00003483929,0.0001987471,0.0001185407,0.00007044573,0.00008071476,0.000002634455],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975942,0.001453494,0.0001698708,0.00008340013,0.000009280592,0.000006577461,0.0002598299,0.000006083853,0.0004172839],"genre_scores_gemma":[0.9990477,0.0002730797,0.0001832465,0.00003089685,0.00001775879,0.000006823072,0.0001847995,0.000001636304,0.0002541371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004418324,"threshold_uncertainty_score":0.008785188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007692552330927287,"score_gpt":0.2488545761665057,"score_spread":0.2411620238355784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}