{"id":"W4414933795","doi":"10.1097/mot.0000000000001254","title":"Use of molecular mismatch to guide induction therapy","year":2025,"lang":"en","type":"article","venue":"Current Opinion in Organ Transplantation","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"","keywords":"Genotyping; Compatibility (geochemistry); Immune system; Antibody therapy; Induction therapy; Selection (genetic algorithm)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001145721,0.00008948259,0.0001410058,0.0002831182,0.00001954774,0.000009489197,0.0000434066,0.00005454856,0.00003781205],"category_scores_gemma":[0.00001182384,0.00008419785,0.00005126166,0.0005295416,0.00002206827,0.00007634639,0.000003023663,0.00008196811,0.000002944646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007231509,"about_ca_system_score_gemma":0.00009298007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009742448,"about_ca_topic_score_gemma":0.000005288461,"domain_scores_codex":[0.9992381,0.00003850737,0.0003179871,0.0001618829,0.000136527,0.0001069957],"domain_scores_gemma":[0.9996973,0.00002656442,0.00004756975,0.0001343674,0.00006633316,0.00002788658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003866036,0.0003384381,0.03594083,0.001127153,0.00008077359,0.000001672718,0.001890405,0.00007659462,0.7220867,0.0004049677,0.002613142,0.2315733],"study_design_scores_gemma":[0.004793576,0.0002775823,0.4093779,0.002639818,0.00003947426,0.00001345242,0.0001468574,0.00004027194,0.5270092,0.0000811799,0.05539844,0.0001822377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840019,0.001696063,0.01011355,0.001336156,0.002142282,0.0005790038,0.00001940347,0.00002878489,0.00008283284],"genre_scores_gemma":[0.9828726,0.01562206,0.0007637713,0.0002695899,0.00006683575,0.0000393369,0.0002703019,0.00001526048,0.00008024133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3734371,"threshold_uncertainty_score":0.3433489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06139018206235605,"score_gpt":0.3660401430430476,"score_spread":0.3046499609806915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}