{"id":"W4414935436","doi":"10.1117/1.jbo.30.s3.s34112","title":"Emerging uses of 5-aminolevulinic-acid-induced protoporphyrin IX in medicine: a review of multifaceted, ubiquitous, molecular diagnostic, therapeutic, and theranostic opportunities","year":2025,"lang":"en","type":"review","venue":"Journal of Biomedical Optics","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Institutes of Health; Princess Margaret Cancer Foundation","keywords":"Protoporphyrin IX; Singlet oxygen; Heme; Protoporphyrin; Photodynamic therapy; Optical imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005443346,0.0007226202,0.0007936558,0.002470965,0.0002786575,0.0008743407,0.0005739245,0.0008002132,0.001712566],"category_scores_gemma":[0.0006525736,0.0002391367,0.0004756498,0.00199894,0.0004641544,0.001477431,0.0005808787,0.001087754,0.0006706844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005695891,"about_ca_system_score_gemma":0.000830785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006339119,"about_ca_topic_score_gemma":0.0008611004,"domain_scores_codex":[0.9997926,0.00003615232,0.00003603962,0.00004362982,0.0000704469,0.00002116442],"domain_scores_gemma":[0.9995932,0.0001965411,0.00006900814,0.00001246661,0.00009636315,0.00003237271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001268332,0.0001480053,0.0007802038,0.03217722,0.0001208874,0.0006391847,0.0002686315,0.0007922009,0.01215168,0.008863121,0.02913764,0.9147944],"study_design_scores_gemma":[0.000009265505,0.000290941,0.00164659,0.004180214,0.0001706862,0.003534937,0.0002048342,0.0003799236,0.00286234,0.003345281,0.9833361,0.00003893323],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003960909,0.9976694,0.0003736191,0.0003685017,0.0002010559,0.000005573001,0.0000120289,0.00000954158,0.0009641072],"genre_scores_gemma":[0.001460401,0.9973341,0.000332738,0.0002217695,0.000241276,0.000006905791,0.00001817462,0.000001790164,0.0003829262],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002470965,"threshold_uncertainty_score":0.005729079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09584566359878603,"score_gpt":0.4264672187714573,"score_spread":0.3306215551726713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}