{"id":"W4414945341","doi":"10.1093/brain/awaf380","title":"A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Petro-Canada","funders":"Eikonizo Therapeutics; Target ALS; Association for Frontotemporal Degeneration","keywords":"Proteostasis; HDAC6; Amyotrophic lateral sclerosis; Frontotemporal dementia; SOD1; Intracellular; Neurodegeneration","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001541492,0.0005621703,0.0004414412,0.0001878155,0.0001774437,0.0002394593,0.0002998124,0.000456007,0.001340769],"category_scores_gemma":[0.00005829649,0.0001678833,0.0003299834,0.0001304772,0.000158495,0.000218977,0.0001776555,0.0006063464,0.0007323491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005286552,"about_ca_system_score_gemma":0.0003430654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008138717,"about_ca_topic_score_gemma":0.003479863,"domain_scores_codex":[0.9999336,0.000006830431,0.000005273972,0.00001279466,0.00002028522,0.00002131118],"domain_scores_gemma":[0.9999748,0.00000220229,0.000006508675,0.00000182922,0.000004177881,0.0000104311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007152813,0.0003121287,0.0005126817,0.0002642777,0.000050852,0.0004404842,0.00004121456,0.0002738243,0.9573175,0.000507331,0.001265411,0.03829892],"study_design_scores_gemma":[0.001218653,0.008352353,0.009033572,0.00005423739,0.0002794116,0.006195913,0.00004782313,0.003191248,0.9032135,0.0003462663,0.06801504,0.000052067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8978242,0.06707241,0.0143507,0.001331452,0.0003797027,0.0005836082,0.001310251,0.0007790216,0.01636863],"genre_scores_gemma":[0.9631155,0.01607738,0.009097191,0.000552138,0.00005621269,0.0002105379,0.001450185,0.00002279333,0.009418108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001340769,"threshold_uncertainty_score":0.004485369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03537990469593175,"score_gpt":0.2860816044087888,"score_spread":0.2507016997128571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}