{"id":"W4414945341","doi":"10.1093/brain/awaf380","title":"A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Petro-Canada","funders":"Eikonizo Therapeutics; Target ALS; Association for Frontotemporal Degeneration","keywords":"Proteostasis; HDAC6; Amyotrophic lateral sclerosis; Frontotemporal dementia; SOD1; Intracellular; Neurodegeneration","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002130049,0.0001117715,0.0001055329,0.00006765427,0.0001400706,0.00007033522,0.00008370156,0.0001290574,0.00001004943],"category_scores_gemma":[0.0001339616,0.0001155916,0.00006004134,0.00006872255,0.00006637993,0.000007512913,0.00008703092,0.00005711223,0.000004075896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002266471,"about_ca_system_score_gemma":0.00008773628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004046647,"about_ca_topic_score_gemma":0.0001768241,"domain_scores_codex":[0.9991409,0.00006059398,0.0001719241,0.000324668,0.00008775058,0.0002141465],"domain_scores_gemma":[0.9996404,0.00001318374,0.0000319733,0.0001887697,0.00006714027,0.00005852016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006800671,0.00002678701,0.0006955327,0.00002348275,0.00004194454,6.12927e-7,0.00002714525,0.000004625977,0.9023882,0.00009712406,0.09305809,0.003568406],"study_design_scores_gemma":[0.002153649,0.0003588215,0.003255307,0.00004996107,0.00002973182,0.000002969295,0.00002878765,0.001700285,0.8357903,0.0001166516,0.1562418,0.0002716758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935167,0.001454449,0.002334248,0.0018816,0.0001957234,0.0003680133,0.00003191802,0.00001277608,0.0002045614],"genre_scores_gemma":[0.9938307,0.00003816924,0.001563644,0.0005760944,0.0004270185,0.0001093139,0.0002353257,0.00001642158,0.003203248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06659793,"threshold_uncertainty_score":0.4713689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03537990469593175,"score_gpt":0.2860816044087888,"score_spread":0.2507016997128571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}