{"id":"W4414947707","doi":"10.1177/17562848251383767","title":"Treatment discontinuation rates due to lack of efficacy through 1 year of maintenance treatment with vedolizumab or subcutaneous infliximab in patients with inflammatory bowel disease: a systematic literature review and meta-analysis","year":2025,"lang":"en","type":"article","venue":"Therapeutic Advances in Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Cilag; Samsung; Celgene; Biogen; Gilead Sciences; United European Gastroenterology; Celltrion; Sanofi; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Vedolizumab; Systematic review; Discontinuation; Infliximab; Inflammatory bowel disease; Ulcerative colitis; Ustekinumab; MEDLINE; Biosimilar","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03089051,0.002222973,0.0191705,0.009667513,0.0005618385,0.003071313,0.002389313,0.002325355,0.001764512],"category_scores_gemma":[0.05627541,0.001814403,0.05807452,0.008376365,0.0007869712,0.001620997,0.001556581,0.001761585,0.0001750278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003257618,"about_ca_system_score_gemma":0.00320259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004721335,"about_ca_topic_score_gemma":0.008005576,"domain_scores_codex":[0.9733825,0.01187807,0.008982352,0.002468543,0.002835629,0.0004528889],"domain_scores_gemma":[0.9423758,0.03973114,0.01327076,0.001447295,0.002736393,0.0004386526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00234129,0.00002676396,0.01037763,0.1914363,0.7859994,0.0001090113,0.00009063946,0.0003903753,0.00009997249,0.00005870323,0.0002556588,0.008814261],"study_design_scores_gemma":[0.0005892238,0.0002634066,0.007924522,0.01647179,0.9734873,0.0001770908,0.00004523683,0.0001887325,0.00008437363,0.00009269662,0.0006491551,0.0000264637],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01177154,0.9864785,0.0005353912,0.0001343236,0.0001033397,0.0002724154,0.0005124683,0.00001791952,0.0001739652],"genre_scores_gemma":[0.3426412,0.6504616,0.00252353,0.0007428483,0.0002714985,0.001848306,0.001224833,0.00003317885,0.0002529822],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03089051,"threshold_uncertainty_score":0.1633666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01145679044322928,"score_gpt":0.2881641360656084,"score_spread":0.2767073456223791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}