{"id":"W4414949924","doi":"10.1007/s40588-025-00256-x","title":"Skin Sentinels: Defensive Effector Molecules Produced by the Skin Microbiome","year":2025,"lang":"en","type":"article","venue":"Current Clinical Microbiology Reports","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Population Health Research Institute","funders":"National Institutes of Health; Weston Family Foundation","keywords":"Microbiome; Effector; Immune system; Commensalism; Pathogen; Function (biology); Human skin; Immunity; Antimicrobial peptides","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005347436,0.0004985461,0.0004719882,0.000408225,0.0003838386,0.001625934,0.0001965888,0.0009952508,0.003396433],"category_scores_gemma":[0.0007194119,0.0001752874,0.0003180089,0.0001287941,0.0004118344,0.0008963716,0.001200972,0.001208355,0.0007186712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002324117,"about_ca_system_score_gemma":0.0002633091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000865465,"about_ca_topic_score_gemma":0.0001508066,"domain_scores_codex":[0.9994777,0.000189229,0.0000248736,0.00007220652,0.000125443,0.0001105502],"domain_scores_gemma":[0.9996008,0.00006321223,0.0001077218,0.00003102998,0.00006703198,0.0001301761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006135633,0.0002048464,0.0146189,0.0007190545,0.00005565289,0.001973928,0.0006276139,0.0001806929,0.9028906,0.004362218,0.003545535,0.07020736],"study_design_scores_gemma":[0.0002536628,0.006298061,0.1389597,0.001748124,0.0003188037,0.02567075,0.008490426,0.005568301,0.545306,0.01945566,0.2477504,0.0001800992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8930805,0.05673819,0.0189249,0.006149917,0.002795306,0.0002697136,0.000537125,0.0003426311,0.02116163],"genre_scores_gemma":[0.9686312,0.01291533,0.009437541,0.001674411,0.0008664897,0.0000668299,0.0003363947,0.00004993732,0.006021846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003396433,"threshold_uncertainty_score":0.01136214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02087731645904124,"score_gpt":0.3611245647281326,"score_spread":0.3402472482690914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}