{"id":"W4414950869","doi":"10.1136/lupus-2025-la.21","title":"21 News and views: Exciting new approaches in therapy, double-hit therapies, JAK inhibitors","year":2025,"lang":"en","type":"article","venue":"Abstracts","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Key (lock); Ruxolitinib; Cancer; Feature (linguistics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004857342,0.001356012,0.001324628,0.001497744,0.001349772,0.007728078,0.001565036,0.01057904,0.03971978],"category_scores_gemma":[0.01412854,0.0005378659,0.001668239,0.001174005,0.002518774,0.006420356,0.001679605,0.01530786,0.01911272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002583083,"about_ca_system_score_gemma":0.002287662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001384136,"about_ca_topic_score_gemma":0.002774085,"domain_scores_codex":[0.9967481,0.0009323753,0.0002885027,0.0003290685,0.001383765,0.0003181534],"domain_scores_gemma":[0.9889953,0.00464715,0.0006838822,0.0003364822,0.002747679,0.002589372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006395771,0.00002232259,0.00007701055,0.0002393704,0.00001698474,0.0001695605,0.00002054977,0.00004018684,0.0001064245,0.001856919,0.9635636,0.03382326],"study_design_scores_gemma":[0.00004111818,0.00003817734,0.0002085761,0.0004139488,0.00002547453,0.0003574928,0.00008670807,0.00004663283,0.00006170463,0.001922269,0.9967827,0.00001523219],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003077857,0.1380845,0.0004809154,0.4745221,0.3656114,0.00003099593,0.0003430114,0.0001577304,0.02046148],"genre_scores_gemma":[0.002632417,0.09746381,0.0005396764,0.2743379,0.593743,0.00003271869,0.0002106557,0.00008878607,0.03095109],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03971978,"threshold_uncertainty_score":0.1328759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1158976483581737,"score_gpt":0.3177012915243983,"score_spread":0.2018036431662246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}