{"id":"W4414961739","doi":"10.1161/res.137.suppl_1.or202","title":"Abstract Or202: Multiscale Platform Identifies Novel Therapeutic Targets for Fibrosis","year":2025,"lang":"en","type":"article","venue":"Circulation Research","topic":"Biological Research and Disease Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Fibrosis; Induced pluripotent stem cell; Extracellular matrix; Cardiac fibrosis; Drug discovery; Myocardial fibrosis; Drug development; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000658744,0.0001058771,0.000116103,0.0001178882,0.0004223724,0.00008908265,0.0002137625,0.0001549954,0.00007287816],"category_scores_gemma":[0.001021658,0.00008761775,0.0001215439,0.0002233271,0.0002360099,0.000008633282,0.0001723753,0.0001392733,0.00002680845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003189376,"about_ca_system_score_gemma":0.0001381623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003353527,"about_ca_topic_score_gemma":0.00006037322,"domain_scores_codex":[0.9986714,0.00003601195,0.0001814296,0.0003840064,0.0002764443,0.0004507269],"domain_scores_gemma":[0.9989377,0.000202178,0.00002533049,0.0002638757,0.0004738677,0.00009707311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003924847,0.0001721766,0.007720076,0.000152214,0.0001468789,6.63964e-7,0.00002729745,0.0001205801,0.9634668,0.001567047,0.01273658,0.01349721],"study_design_scores_gemma":[0.001958991,0.0002437015,0.8279137,0.00006138295,0.00001839391,7.09144e-7,0.0005089263,0.001576691,0.09670639,0.0100831,0.06061525,0.0003127546],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9399227,0.01299935,0.02983448,0.001805361,0.0002854087,0.002078413,0.0003370128,0.00005473884,0.01268253],"genre_scores_gemma":[0.9970818,0.0002143791,0.0001775033,0.0001134239,0.0001170149,0.0002607107,0.0003185849,0.000009548258,0.001707045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8667604,"threshold_uncertainty_score":0.3572948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1065279202653056,"score_gpt":0.4193881097810698,"score_spread":0.3128601895157642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}