{"id":"W4414961739","doi":"10.1161/res.137.suppl_1.or202","title":"Abstract Or202: Multiscale Platform Identifies Novel Therapeutic Targets for Fibrosis","year":2025,"lang":"en","type":"article","venue":"Circulation Research","topic":"Biological Research and Disease Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Fibrosis; Induced pluripotent stem cell; Extracellular matrix; Cardiac fibrosis; Drug discovery; Myocardial fibrosis; Drug development; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003220043,0.0007914588,0.0006734112,0.0007516834,0.0001948139,0.000704225,0.0004422853,0.0006074524,0.00741936],"category_scores_gemma":[0.0001877383,0.000209266,0.0005972998,0.0003623587,0.000182165,0.0004187402,0.0005587001,0.001031367,0.001563654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003767918,"about_ca_system_score_gemma":0.0004066806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004220454,"about_ca_topic_score_gemma":0.001007461,"domain_scores_codex":[0.9997823,0.00002347866,0.000009914602,0.00004812008,0.00008667705,0.00004955713],"domain_scores_gemma":[0.999931,0.000008491261,0.00001187311,0.000009527126,0.00001370029,0.00002539714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003206129,0.0002854324,0.0003571194,0.0003271465,0.00004092936,0.0001713685,0.00002312727,0.0009849744,0.9619746,0.000978154,0.003299031,0.03123752],"study_design_scores_gemma":[0.0003180964,0.005199578,0.003429668,0.0001038016,0.0001831061,0.0007264604,0.0000503477,0.006225409,0.9339545,0.0006095265,0.04913775,0.0000617561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8606171,0.02798646,0.0418337,0.002728379,0.0008259957,0.001638303,0.01100337,0.003600013,0.04976664],"genre_scores_gemma":[0.9336339,0.01029313,0.02469206,0.001284248,0.0001309432,0.0007739338,0.006284248,0.0002174053,0.02269002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00741936,"threshold_uncertainty_score":0.02482021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1065279202653056,"score_gpt":0.4193881097810698,"score_spread":0.3128601895157642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}