{"id":"W4414963642","doi":"10.1136/gutjnl-2025-basl.7","title":"O8 Linerixibat significantly improves cholestatic pruritus in primary biliary cholangitis (PBC): results of the pivotal phase 3 GLISTEN trial","year":2025,"lang":"en","type":"article","venue":"","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Placebo; Adverse effect; Clinical endpoint; Mean difference; Clinical trial; Quality of life (healthcare)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001059872,0.0005088673,0.001083107,0.0001224526,0.0001987663,0.0004755111,0.0003066673,0.0007023323,0.005230898],"category_scores_gemma":[0.0008638618,0.0001598011,0.001100929,0.0001985,0.0003948102,0.0003198601,0.0001710415,0.001089359,0.0006894453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002919086,"about_ca_system_score_gemma":0.0005885201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006264544,"about_ca_topic_score_gemma":0.001711258,"domain_scores_codex":[0.9996645,0.0001821949,0.0000233933,0.00003207563,0.00004547273,0.00005236181],"domain_scores_gemma":[0.99951,0.0001347825,0.0001358975,0.00002996874,0.00003986186,0.0001493004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.786837,0.007526026,0.004112449,0.001962465,0.001864918,0.000220801,0.000158926,0.001019433,0.0272818,0.0002081701,0.009316638,0.1594914],"study_design_scores_gemma":[0.7651505,0.1986309,0.0265567,0.0001276246,0.001028073,0.0003636621,0.00005628527,0.0009284882,0.002804773,0.0002250653,0.004095745,0.00003215334],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847884,0.00766921,0.0004495283,0.001195498,0.000206982,0.0009573392,0.001467664,0.0001363102,0.003129062],"genre_scores_gemma":[0.9907153,0.003015463,0.0008521647,0.001302892,0.0002375344,0.0005714382,0.001210204,0.00003045691,0.002064508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005230898,"threshold_uncertainty_score":0.01749909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01217385818454133,"score_gpt":0.2895844624261331,"score_spread":0.2774106042415918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}