{"id":"W4414964689","doi":"10.1128/spectrum.00976-25","title":"Identification of plasmid-mediated tigecycline resistance <i>tet</i> (x4) and New Delhi metallo-β-lactamase (NDM) in an <i>Escherichia coli</i> isolate from Canada","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; University of Toronto; Public Health Agency of Canada; Mount Sinai Hospital","funders":"","keywords":"Tigecycline; Plasmid; Identification (biology); Mobile genetic elements; clone (Java method); Gene; Antibiotic resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001655108,0.0002340607,0.0003704713,0.00006745665,0.0000529503,0.00002013314,0.0003023643,0.0002646015,0.00002364867],"category_scores_gemma":[0.00008944756,0.0002443254,0.0000431663,0.0002069674,0.0001955693,0.00001006853,0.00009889858,0.0001538475,0.000002374873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006303201,"about_ca_system_score_gemma":0.0005891816,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02962368,"about_ca_topic_score_gemma":0.6852559,"domain_scores_codex":[0.9982876,0.0001435637,0.0005978177,0.0006033036,0.00004387466,0.0003238397],"domain_scores_gemma":[0.9990849,0.00005115225,0.0002471039,0.0004899235,0.00004511909,0.00008178828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004296209,0.00005230458,0.03085498,0.00002173984,0.00007176169,0.000007089465,0.000019813,0.00000872255,0.964901,0.00005167532,0.003560676,0.00002063567],"study_design_scores_gemma":[0.001161731,0.00007551736,0.08075532,0.00004279118,0.00004546207,0.000002425773,0.00005951101,0.00002806914,0.8979138,0.0002467773,0.01939338,0.0002752588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995664,0.001733558,0.0005020866,0.000987797,0.0003248983,0.0002327856,0.0004237512,0.00001138282,0.0001197348],"genre_scores_gemma":[0.9959238,0.0003126241,0.0005868993,0.0008391168,0.00005639763,0.000004272113,0.0009204225,0.00001955409,0.001336945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6556323,"threshold_uncertainty_score":0.9963302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004551492818075829,"score_gpt":0.2155733684077131,"score_spread":0.2110218755896373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}