{"id":"W4414969360","doi":"10.21203/rs.3.rs-7697517/v1","title":"Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Discovery Centre","funders":"University of California, San Francisco; National Institutes of Health; Biobanco Vasco; Pennsylvania State University; Medicines for Malaria Venture; Comunidad de Madrid; Huck Institutes of the Life Sciences; Centro Nacional de Processamento de Alto Desempenho em São Paulo; Bill and Melinda Gates Foundation","keywords":"Piperaquine; Efflux; Plasmodium falciparum; Chloroquine; Drug resistance; Multiple drug resistance; Mutant; Resistance mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001420897,0.0002109158,0.0003197,0.00009624988,0.00008246121,0.000231283,0.0002541373,0.0002797495,0.006808841],"category_scores_gemma":[0.0002799779,0.0001452117,0.0002130541,0.00008672231,0.0001913393,0.0001904033,0.0002415048,0.0007237876,0.0006298064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000184046,"about_ca_system_score_gemma":0.0001857739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005193118,"about_ca_topic_score_gemma":0.0005518019,"domain_scores_codex":[0.9998908,0.0000184785,0.000007871036,0.00002013848,0.00002743332,0.00003529213],"domain_scores_gemma":[0.9999262,0.00001619704,0.00001910556,0.00001284345,0.000007085727,0.00001865056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008164261,0.0001018389,0.0003255084,0.00004911383,0.00001760892,0.00005612261,0.000008407836,0.00019001,0.9934998,0.0002269134,0.0003559508,0.00435239],"study_design_scores_gemma":[0.0003324343,0.001748919,0.008725486,0.00001064687,0.00003063574,0.0004431549,0.00002861669,0.002714157,0.9817511,0.0002250485,0.00397883,0.00001093583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954959,0.0004471099,0.001172183,0.000158859,0.00005979024,0.00004461853,0.0004977597,0.00008992929,0.002033752],"genre_scores_gemma":[0.995895,0.0002135276,0.0009205464,0.00005251502,0.00001828344,0.00002202814,0.0004774163,0.00002587808,0.002374822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006808841,"threshold_uncertainty_score":0.02277786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03882739256269731,"score_gpt":0.364955391514359,"score_spread":0.3261279989516617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}