{"id":"W4414976055","doi":"10.1016/j.molmed.2025.09.006","title":"BH3 mimetic therapies for CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia","year":2025,"lang":"en","type":"article","venue":"Trends in Molecular Medicine","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canada Research Chairs; Fonds de Recherche du Québec - Santé; Cole Foundation; Canadian Institutes of Health Research; Cancer Research Society; Leukemia and Lymphoma Society","keywords":"Acute megakaryoblastic leukemia; Disease; Leukemia; Gene; Mechanism (biology); Fusion protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451784,0.0002080191,0.0002779705,0.000224055,0.0001907852,0.000258267,0.0002873923,0.0002201901,0.003649002],"category_scores_gemma":[0.0001180576,0.0000621935,0.000234151,0.0002864922,0.0001618023,0.0001784917,0.0003060058,0.0008355483,0.000567765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005576462,"about_ca_system_score_gemma":0.0003268331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006218849,"about_ca_topic_score_gemma":0.00234453,"domain_scores_codex":[0.9999377,0.000007445457,0.000003628141,0.000007070263,0.00001806443,0.00002614004],"domain_scores_gemma":[0.999964,0.00000554512,0.00001008173,0.000003633216,0.0000051239,0.00001151199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008645642,0.001025718,0.005962498,0.001442206,0.0004090443,0.003345414,0.000243684,0.003885859,0.351964,0.009065183,0.03533901,0.5786718],"study_design_scores_gemma":[0.009633183,0.0104868,0.04056285,0.0004533852,0.001061367,0.01396774,0.0005968691,0.007329664,0.3783664,0.008553887,0.528904,0.00008386088],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9094299,0.05150989,0.007157969,0.003337975,0.0005209843,0.0002612782,0.001336904,0.0007862832,0.02565875],"genre_scores_gemma":[0.9758414,0.01167541,0.003372137,0.0009133409,0.0000856246,0.0001728082,0.001716987,0.00006548526,0.006156711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003649002,"threshold_uncertainty_score":0.01220709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01154927894604091,"score_gpt":0.3064832798711979,"score_spread":0.294934000925157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}