{"id":"W4414978321","doi":"10.1016/j.biopsych.2025.10.001","title":"Transcriptional Profiling of the Cortico-Accumbal Pathway Reveals Sex-Specific Alterations Underlying Stress Susceptibility","year":2025,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Sentinelle Nord, Université Laval; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Transcriptional activity; Chronic stress; Transcriptional regulation; Differential (mechanical device); Gene expression profiling; Transcriptome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007524637,0.0001463835,0.000194646,0.00003973193,0.0003144396,0.00004156673,0.0004026397,0.0001218175,0.000131886],"category_scores_gemma":[0.0002069862,0.00009043195,0.0001989789,0.0003536944,0.0002969599,0.00005183138,0.00007304917,0.0002213754,0.000005133921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002825755,"about_ca_system_score_gemma":0.0001296475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000576113,"about_ca_topic_score_gemma":0.00001929973,"domain_scores_codex":[0.9982635,0.0003546118,0.0004627443,0.0004789889,0.0001937531,0.0002464405],"domain_scores_gemma":[0.9991215,0.0002693967,0.0001217277,0.0004036564,0.0000378512,0.00004580855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001326356,0.0002425468,0.2060697,0.00002686166,0.000005415325,5.327339e-7,0.00002552552,0.00004110692,0.6935687,0.09713326,0.00008281395,0.002670905],"study_design_scores_gemma":[0.0005512343,0.000206379,0.870245,0.0001146905,0.00001060974,0.000004857459,0.0003909205,0.000182097,0.1050666,0.0218566,0.001155231,0.0002158116],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928643,0.0004594728,0.002266168,0.0009067492,0.001382833,0.0004456934,0.0001945233,0.00005709921,0.001423195],"genre_scores_gemma":[0.9983228,0.000122188,0.0005502938,0.000614752,0.00007075807,0.00003773587,0.0000055986,0.000005006982,0.0002708372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6641753,"threshold_uncertainty_score":0.3687708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1058039696853935,"score_gpt":0.3305018114646142,"score_spread":0.2246978417792206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}