{"id":"W4414980620","doi":"10.3390/cells14191565","title":"Dual Targeting of Smoothened, a Key Regulator in the Hedgehog Pathway, and BCR-ABL1 Effectively Eradicates Drug-Insensitive Stem/Progenitor Cells in Chronic Myeloid Leukemia","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Leukemia & Lymphoma Society of Canada; Terry Fox Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Smoothened; Myeloid leukemia; Hedgehog signaling pathway; Leukemia; Progenitor cell; Gene knockdown; Stem cell; Cancer stem cell; Cancer cell; Hedgehog","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009682385,0.0002278536,0.0002554293,0.0001695476,0.00008679718,0.0002024535,0.0001056997,0.0001276352,0.000615351],"category_scores_gemma":[0.0000346507,0.0001001178,0.000147823,0.0001268847,0.0001366398,0.00011759,0.0001473775,0.0005129246,0.000147398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001551712,"about_ca_system_score_gemma":0.0001390326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002589039,"about_ca_topic_score_gemma":0.0006947208,"domain_scores_codex":[0.9999352,0.00000732893,0.000005591888,0.00001226602,0.00002236017,0.00001724522],"domain_scores_gemma":[0.9999839,0.000001686657,0.00000509707,0.000001949944,0.000001478767,0.000005908048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00013687,0.0000489639,0.0001337757,0.00003755295,0.000005240148,0.00001663684,0.000008440019,0.0001305469,0.9959986,0.00005239851,0.00006677896,0.003364221],"study_design_scores_gemma":[0.00007939967,0.001314416,0.007067107,0.000006081583,0.00004026839,0.000243536,0.00003223795,0.002259277,0.985042,0.00008370409,0.003826154,0.000005855986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966236,0.001291999,0.001151821,0.0000665167,0.00001384741,0.00002510997,0.0002066161,0.00007160741,0.0005487421],"genre_scores_gemma":[0.9959667,0.0009948483,0.001304307,0.00004114581,0.000005991652,0.00003566093,0.0003491951,0.00001100467,0.001291146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000615351,"threshold_uncertainty_score":0.002058566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006115623545899142,"score_gpt":0.2179230941681158,"score_spread":0.2118074706222167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}