{"id":"W4414980620","doi":"10.3390/cells14191565","title":"Dual Targeting of Smoothened, a Key Regulator in the Hedgehog Pathway, and BCR-ABL1 Effectively Eradicates Drug-Insensitive Stem/Progenitor Cells in Chronic Myeloid Leukemia","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Leukemia & Lymphoma Society of Canada; Terry Fox Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Smoothened; Myeloid leukemia; Hedgehog signaling pathway; Leukemia; Progenitor cell; Gene knockdown; Stem cell; Cancer stem cell; Cancer cell; Hedgehog","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000803742,0.0002729586,0.0003771285,0.0001319328,0.00009267784,0.00002417009,0.0002110032,0.0001755061,0.000001806843],"category_scores_gemma":[0.00007292601,0.0002246488,0.00009449796,0.0002956533,0.0002654,0.00000566048,0.0002008297,0.0002089525,0.000004513105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001623694,"about_ca_system_score_gemma":0.0003799609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000130368,"about_ca_topic_score_gemma":0.0001153666,"domain_scores_codex":[0.9981384,0.0003838929,0.0004162118,0.0005298728,0.0001467073,0.000384871],"domain_scores_gemma":[0.9991785,0.0002302852,0.000144594,0.0003178545,0.00008429625,0.00004442672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008557051,0.00005105521,0.001473995,0.0002039636,0.00006799817,0.0000203948,0.001555717,0.0002190037,0.9945096,0.0000455613,0.0005178729,0.001249231],"study_design_scores_gemma":[0.001012695,0.0001522833,0.003901628,0.0001745398,0.00002229566,0.000002896702,0.001188609,0.0001485506,0.9902697,0.00005759028,0.002853698,0.0002154952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926783,0.005914296,0.00004838625,0.00008412478,0.0001678827,0.0006734421,0.00004365077,0.00001117898,0.0003787216],"genre_scores_gemma":[0.9988822,0.000287248,0.0001550923,0.0001287552,0.0001457534,0.00007217321,0.00001594973,0.00002533871,0.0002875392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006203834,"threshold_uncertainty_score":0.9160911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006115623545899142,"score_gpt":0.2179230941681158,"score_spread":0.2118074706222167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}