{"id":"W4414980796","doi":"10.1242/jcs.263886","title":"Characterisation of a primary ciliary dyskinesia model generated from <i>BMI1</i> -transduced basal epithelial cells","year":2025,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Great Ormond Street Hospital for Children; University College London; Imperial College London; Newlife – The Charity for Disabled Children; University of Leicester; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; National Institute for Health and Care Research; NIHR Great Ormond Street Hospital Biomedical Research Centre; Newlife the Charity for Disabled Children; University of Dundee","keywords":"Primary ciliary dyskinesia; Cilium; Motile cilium; Ciliogenesis; Phenotype; Basal body; Respiratory epithelium; Dynein; Epithelium; Cystic fibrosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009258146,0.0001180869,0.0003928833,0.0003671336,0.00007592679,0.00003599773,0.00037379,0.00005107854,0.00004417706],"category_scores_gemma":[0.0001872488,0.000090543,0.000106878,0.0008001327,0.000366139,0.0004726963,0.00005364788,0.000263583,0.00000353611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001641417,"about_ca_system_score_gemma":0.002123894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002017318,"about_ca_topic_score_gemma":0.000001530171,"domain_scores_codex":[0.9977916,0.00004663972,0.0006167128,0.0002112186,0.001070582,0.0002632592],"domain_scores_gemma":[0.9983547,0.0001370696,0.0003414238,0.0002259749,0.0007499476,0.0001909112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006563429,0.0001731817,0.0004585253,0.00007106035,0.00001366645,0.00001937064,0.0001631041,0.0008690472,0.994665,0.000009131006,0.0003392463,0.002562296],"study_design_scores_gemma":[0.001307857,0.0002348595,0.01925115,0.0001785129,0.00005920462,0.000007571733,0.00003351991,0.02279778,0.955264,0.0005806984,0.0002142693,0.00007051554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977582,0.0002989933,0.01948424,0.0006283816,0.000347853,0.0001748882,0.00003139072,0.000007319511,0.001444898],"genre_scores_gemma":[0.9795394,0.0002078182,0.01951197,0.0003281638,0.0001219177,0.000001639479,0.000004695518,0.000007009378,0.0002773765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03940097,"threshold_uncertainty_score":0.3767697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226698462073041,"score_gpt":0.2746277759570185,"score_spread":0.2623607913362881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}