{"id":"W4414985387","doi":"10.1186/s13063-025-09052-w","title":"Core outcome domain sets for clinical trials in epidermolysis bullosa — a COSEB protocol to achieve consensus on “what” to measure","year":2025,"lang":"en","type":"article","venue":"Trials","topic":"Delphi Technique in Research","field":"Social Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Protocol (science); Clinical trial; Epidermolysis bullosa; Measure (data warehouse); Domain (mathematical analysis); MEDLINE; Outcome (game theory)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":["metaresearch"],"domain":"methods","study_design":"qualitative","genre":"protocol","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":["metaresearch"],"domain":"methods","study_design":"design_other","genre":"protocol","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.2886461,0.0002970392,0.002917347,0.000771074,0.0003384086,0.0003672543,0.0009667775,0.0005707579,0.0001899907],"category_scores_gemma":[0.4138233,0.0002469133,0.0008587941,0.001602724,0.0002499782,0.00008221234,0.0001908867,0.0004689823,0.0001499107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004705923,"about_ca_system_score_gemma":0.001179963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006945869,"about_ca_topic_score_gemma":0.001711611,"domain_scores_codex":[0.9634592,0.02792189,0.005240677,0.001003382,0.001362445,0.001012436],"domain_scores_gemma":[0.9119738,0.08548982,0.0007486727,0.0007927152,0.0004915691,0.0005034227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.04527767,0.00152505,0.005161072,0.0002447787,0.0004680903,0.000258293,0.004162813,0.00004043197,0.002170445,0.05975099,0.4633187,0.4176216],"study_design_scores_gemma":[0.02547182,0.003589343,0.002388717,0.002040182,0.0002396278,0.000004273173,0.0100559,0.00003217887,0.003247667,0.1752876,0.7763153,0.001327283],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.04506928,0.00003367328,0.00272114,0.1974392,0.001645096,0.7452746,0.000291461,0.0003733335,0.007152188],"genre_scores_gemma":[0.1056187,0.00003282346,0.02753567,0.007312172,0.001404453,0.8536478,0.00001469912,0.00008824834,0.00434552],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.4162943,"threshold_uncertainty_score":0.9999983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.841677602741952,"score_gpt":0.704296546695888,"score_spread":0.137381056046064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}