{"id":"W4414990262","doi":"10.1162/imag.a.967","title":"Investigating the impact of sex and reproductive aging on latent signatures of modifiable dementia risk factors","year":2025,"lang":"en","type":"article","venue":"Imaging Neuroscience","topic":"Demographic Trends and Gender Preferences","field":"Social Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada First Research Excellence Fund; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Dementia; Cohort; Risk factor; Neuroimaging; Disease; Brain aging; Partial least squares regression; Latent variable","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002580805,0.0004604733,0.000296544,0.0006889389,0.0003112339,0.0007775549,0.0003168641,0.0002843336,0.002398751],"category_scores_gemma":[0.006982421,0.0002503251,0.001236116,0.0007789651,0.0005158992,0.0005663983,0.0006533764,0.0004662668,0.0001714867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002297471,"about_ca_system_score_gemma":0.0005872457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005031905,"about_ca_topic_score_gemma":0.009818755,"domain_scores_codex":[0.9988812,0.0005795158,0.00005145988,0.0002824736,0.00009896927,0.0001064364],"domain_scores_gemma":[0.9968718,0.001434497,0.0007460981,0.0006493653,0.0001816386,0.0001167227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002177074,0.00003545743,0.9787349,0.00003804665,0.0007683389,0.00008594002,0.000412962,0.0004918133,0.002159661,0.000611419,0.0001806785,0.01626324],"study_design_scores_gemma":[0.000004817801,0.000114071,0.9949524,0.00001149544,0.0001213112,0.0001323542,0.0001823944,0.002517178,0.000486901,0.001065258,0.0004043187,0.000007365484],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876265,0.0005675283,0.009965629,0.0001900045,0.00001667866,0.0000233624,0.0008154397,0.00003180861,0.0007630755],"genre_scores_gemma":[0.9969848,0.0001210633,0.002235305,0.00003407697,0.00001070075,0.00002161731,0.000309309,0.00001117239,0.0002720336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005031905,"threshold_uncertainty_score":0.01364875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03630712471381246,"score_gpt":0.3311111293938389,"score_spread":0.2948040046800264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}