{"id":"W4414993271","doi":"10.1186/s12943-025-02463-y","title":"Advances in RNA-based cancer therapeutics: pre-clinical and clinical implications","year":2025,"lang":"en","type":"review","venue":"Molecular Cancer","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"RNA interference; microRNA; Cancer; Small interfering RNA; Gene silencing; Clinical trial; Immunotherapy; RNA; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003301699,0.0007108237,0.0008974578,0.0007100029,0.0003991385,0.002138886,0.0006138184,0.001838606,0.007574259],"category_scores_gemma":[0.002345394,0.0002713473,0.0006247021,0.0006213809,0.00135826,0.002608555,0.00117919,0.003360487,0.003987484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001060152,"about_ca_system_score_gemma":0.00183961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004788602,"about_ca_topic_score_gemma":0.001024083,"domain_scores_codex":[0.9990652,0.0003230679,0.00008429981,0.0001253994,0.000291288,0.0001107536],"domain_scores_gemma":[0.997673,0.001263806,0.0001977848,0.0001001073,0.0005722062,0.000193154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004036172,0.0002744276,0.0006838785,0.008979269,0.00007759212,0.000556957,0.0002711886,0.0008464559,0.02592157,0.03407487,0.03211414,0.895796],"study_design_scores_gemma":[0.00005370038,0.0008937581,0.001139383,0.001966553,0.00008265233,0.001676262,0.0001541615,0.0004385028,0.01262293,0.01502186,0.9659021,0.00004807111],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002166619,0.9648377,0.005395432,0.01674671,0.001726546,0.00004146423,0.00009865074,0.0000978918,0.008888954],"genre_scores_gemma":[0.02401866,0.9539682,0.006330635,0.007608653,0.00305398,0.00008908307,0.00020746,0.00004141334,0.004681869],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007574259,"threshold_uncertainty_score":0.02533841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05547127883058611,"score_gpt":0.4640127763123402,"score_spread":0.4085414974817541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}