{"id":"W4414997569","doi":"10.1038/s41380-025-03280-x","title":"Cortical microstructure is associated with disease severity and clinical progression in genetic frontotemporal dementia: a GENFI study","year":2025,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Occupational Cancer Research Centre; Western University; McGill University; Douglas Mental Health University Institute; University of Toronto; Montreal Neurological Institute and Hospital; Université Laval","funders":"NIHR Cambridge Biomedical Research Centre; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Faculté de Médecine, Université Laval; Demensfonden; George Institute for Global Health; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Universitat Autònoma de Barcelona; Stichting Dioraphte; Medical Research Council; Università degli Studi di Brescia; European Regional Development Fund; Universitat de Barcelona; Universidade de Lisboa; Åhlén-stiftelsen; Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta; EU Joint Programme – Neurodegenerative Disease Research; Università degli Studi di Milano; Università degli Studi di Firenze; Vetenskapsrådet; Cambridge University Hospitals; Stockholms Läns Landsting; KU Leuven; Universidade de Coimbra; Imperial College London; University of Toronto; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institute for Health and Care Research; Alzheimer Society; Institut National de la Santé et de la Recherche Médicale; Ministero della Salute; Alzheimer Nederland; Eberhard Karls Universität Tübingen; ZonMw; University of Cambridge; Sorbonne Université; McGill University; Alzheimer's Association; Global Brain Health Institute; Weston Brain Institute; Alzheimerfonden; Karolinska Institutet; Université de Lille; Sunnybrook Research Institute; Université Laval; Gun och Bertil Stohnes Stiftelse; Neuroförbundet; Stiftelsen för Gamla Tjänarinnor; Barcelona Supercomputing Center; Deutsches Zentrum für Neurodegenerative Erkrankungen","keywords":"Frontotemporal dementia; C9orf72; Clinical Dementia Rating; Dementia; Tauopathy; Disease; Alzheimer's disease; Neuroimaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009867164,0.0006220298,0.0003968475,0.0008834238,0.0005389813,0.0006229853,0.0005914349,0.0006965983,0.001691966],"category_scores_gemma":[0.001908602,0.0003337207,0.0006096599,0.0008336572,0.0005072281,0.0003253291,0.0005799776,0.0005047512,0.0002270754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003875921,"about_ca_system_score_gemma":0.0003048637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01541596,"about_ca_topic_score_gemma":0.02024551,"domain_scores_codex":[0.9996917,0.00008348387,0.00002436173,0.0001160496,0.00004123295,0.00004326908],"domain_scores_gemma":[0.9989097,0.0002348395,0.000384905,0.0001942898,0.0001041595,0.0001721582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004379517,0.0000378428,0.995995,0.00001067605,0.0001807595,0.0003965148,0.0003678554,0.00006278462,0.001010615,0.00002500076,0.00009451345,0.001380455],"study_design_scores_gemma":[0.000005209816,0.00005169912,0.9994935,0.000002048366,0.00003327521,0.0002259204,0.00004256853,0.00005214437,0.00002436629,0.00001051674,0.00005693627,0.000001816442],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994702,0.00008857271,0.0000488944,0.00001519997,0.000002113385,0.000004117821,0.0001893969,0.000002821016,0.0001786604],"genre_scores_gemma":[0.9993697,0.00003992424,0.0000972326,0.00001584923,0.000004945301,0.000006039184,0.0002793331,0.00000274957,0.0001841389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01541596,"threshold_uncertainty_score":0.03065246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01058674357992722,"score_gpt":0.3523073162753733,"score_spread":0.341720572695446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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