{"id":"W4414997619","doi":"10.1111/acel.70249","title":"Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy","year":2025,"lang":"en","type":"article","venue":"Aging Cell","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; LEO Fondet; University College London Hospitals NHS Foundation Trust; Medical Research Council; Directorate for Biological Sciences; Barts Charity; Dunhill Medical Trust; University of Dundee; LEO Pharma Research Foundation; Versus Arthritis; Alzheimer’s Research UK","keywords":"Monocyte; Immune system; Phenotype; Hormone replacement therapy (female-to-male); Inflammation; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004500039,0.0001565908,0.0002697279,0.0001065089,0.0001083114,0.00001671506,0.0001038616,0.0001380205,0.00002665264],"category_scores_gemma":[0.0000516277,0.0001434671,0.00001886664,0.0001296006,0.00008682565,0.0000589701,0.00005723687,0.0001692527,0.00002399495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006043787,"about_ca_system_score_gemma":0.00003369918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003472568,"about_ca_topic_score_gemma":0.00002612693,"domain_scores_codex":[0.9987347,0.0003714077,0.0002566945,0.0003751097,0.00002515736,0.0002369043],"domain_scores_gemma":[0.9994347,0.0001160503,0.0001365358,0.0002690307,0.00003092393,0.00001275096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001251329,0.00009680818,0.1784039,0.0000411089,0.0001117328,0.00001313252,0.0006677427,8.94092e-7,0.8112893,0.00003855638,0.008858197,0.0003535656],"study_design_scores_gemma":[0.007964595,0.0002681112,0.5753167,0.000463368,0.00003929124,0.000004600722,0.001105334,0.000001547309,0.3908344,0.0002477271,0.02337334,0.0003810022],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9194867,0.07713027,0.000009098789,0.0001851328,0.0001811827,0.0003313196,0.0000104526,0.00005727366,0.002608563],"genre_scores_gemma":[0.9911199,0.0009599747,0.00001106091,0.0001332639,0.000008088911,0.00003441426,0.00006346413,0.00001034417,0.007659545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4204549,"threshold_uncertainty_score":0.585042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01137555573195984,"score_gpt":0.2334317726434366,"score_spread":0.2220562169114767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}