{"id":"W4414997648","doi":"10.1111/his.70021","title":"<scp> <i>CDKN2A</i> </scp> deletion in p16‐negative/ <scp>HPV</scp> ‐positive head and neck squamous cell carcinoma: Highlighting the molecular basis behind the limitation of relying on p16 immunohistochemistry as a surrogate marker for <scp>HPV</scp> involvement","year":2025,"lang":"en","type":"article","venue":"Histopathology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Ottawa Hospital; Hospital for Sick Children; University of British Columbia; University of Ottawa; University of Toronto","funders":"","keywords":"Immunohistochemistry; Head and neck; Anatomical pathology; Head and neck squamous-cell carcinoma; Surrogate endpoint; Predictive marker","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007608823,0.0004523658,0.0002525428,0.0009944584,0.0006615845,0.0006624136,0.0006666487,0.0006934343,0.0009666728],"category_scores_gemma":[0.002927108,0.0002843308,0.0002361782,0.0004421367,0.001103053,0.0005847215,0.0006305426,0.000488073,0.0004261075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000398939,"about_ca_system_score_gemma":0.0003755508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001061462,"about_ca_topic_score_gemma":0.001759044,"domain_scores_codex":[0.9993827,0.0001129101,0.00009396768,0.0001357198,0.0001590913,0.0001155233],"domain_scores_gemma":[0.9985215,0.0005233312,0.0004237356,0.0002192558,0.0001458649,0.0001663448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001438749,0.00004338752,0.8164604,0.00008604365,0.00002489146,0.160989,0.0007760981,0.0002832941,0.01140119,0.0001104323,0.0003076144,0.009373765],"study_design_scores_gemma":[0.00001120698,0.0002482002,0.2104175,0.00003141423,0.00005636848,0.7692787,0.0009409258,0.0009437806,0.01659982,0.0001613282,0.001295408,0.00001536903],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982071,0.0002958001,0.0005470443,0.00004912102,0.000007407464,0.00001996406,0.00002406422,0.00001396646,0.0008356378],"genre_scores_gemma":[0.9995255,0.00009000864,0.0002583794,0.00001545693,0.00001046259,0.000005948961,0.00002314832,0.000005295583,0.00006578012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001061462,"threshold_uncertainty_score":0.004023969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382755986216145,"score_gpt":0.2680824861996733,"score_spread":0.2542549263375119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}