{"id":"W4414997648","doi":"10.1111/his.70021","title":"<scp> <i>CDKN2A</i> </scp> deletion in p16‐negative/ <scp>HPV</scp> ‐positive head and neck squamous cell carcinoma: Highlighting the molecular basis behind the limitation of relying on p16 immunohistochemistry as a surrogate marker for <scp>HPV</scp> involvement","year":2025,"lang":"en","type":"article","venue":"Histopathology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Ottawa Hospital; Hospital for Sick Children; University of British Columbia; University of Ottawa; University of Toronto","funders":"","keywords":"Immunohistochemistry; Head and neck; Anatomical pathology; Head and neck squamous-cell carcinoma; Surrogate endpoint; Predictive marker","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001261074,0.0005345808,0.0009378014,0.000313509,0.0005979388,0.00003179196,0.0002899597,0.0003457354,0.00000311112],"category_scores_gemma":[0.002883016,0.00041799,0.0002677187,0.0004570636,0.0005670357,0.00009755481,0.0002189455,0.0006958806,0.000008838861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006959639,"about_ca_system_score_gemma":0.0003328362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003797841,"about_ca_topic_score_gemma":0.0001433923,"domain_scores_codex":[0.9965084,0.0004755246,0.0009268989,0.0008994794,0.0004115356,0.0007782252],"domain_scores_gemma":[0.9942418,0.00400982,0.0005542166,0.0006520656,0.0004348684,0.0001072462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004285699,0.00137724,0.05585827,0.002527136,0.0001712908,0.0006008736,0.06148663,0.0001332634,0.847435,0.002091269,0.02434368,0.003546754],"study_design_scores_gemma":[0.01187956,0.003118842,0.5331309,0.0009679623,0.001049602,0.0001619825,0.01957494,0.0005619111,0.3968693,0.00121387,0.03127022,0.0002009823],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9637634,0.01239652,0.0002985609,0.00120532,0.0003790531,0.001720209,0.00006052386,0.00005607968,0.02012035],"genre_scores_gemma":[0.9915964,0.0003676221,0.0006587635,0.002775066,0.00009862668,0.0007195931,0.00009649785,0.00006600223,0.003621432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4772726,"threshold_uncertainty_score":0.9998272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382755986216145,"score_gpt":0.2680824861996733,"score_spread":0.2542549263375119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}