{"id":"W4414998083","doi":"10.1016/j.jobab.2025.10.001","title":"Antioxidative lignin materials attenuate type 2 diabetes mellitus (T2DM) progression by preserving glutathione via insulin receptor substrate 1/phosphoinositide 3-kinase/protein kinase B (IRS1/PI3K/AKT) axis","year":2025,"lang":"en","type":"article","venue":"Journal of Bioresources and Bioproducts","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China","keywords":"Type 2 Diabetes Mellitus; Lignin; Insulin; Insulin receptor; Oxidative stress; Antioxidant; Diabetes mellitus; IRS1","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001087166,0.0003812576,0.0001798844,0.0003468037,0.0001180167,0.0001903589,0.0001127096,0.0002498216,0.0008759926],"category_scores_gemma":[0.00005825098,0.00008650954,0.0002486368,0.0002018273,0.000115378,0.0002323587,0.0001446461,0.0005553396,0.00007247157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001343839,"about_ca_system_score_gemma":0.0001732137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002796846,"about_ca_topic_score_gemma":0.0007907494,"domain_scores_codex":[0.9999529,0.000007078359,0.000003166809,0.0000083282,0.00001378299,0.00001465006],"domain_scores_gemma":[0.9999723,0.000002222285,0.00001119943,0.000001914873,0.000004726542,0.000007511114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002934612,0.0002411521,0.0003639479,0.000212299,0.00002961149,0.00006365273,0.00001680363,0.0001412761,0.9839175,0.0001720132,0.0001305861,0.01441775],"study_design_scores_gemma":[0.0001134838,0.002949633,0.01008248,0.00004165449,0.0001529929,0.0003400832,0.00005871138,0.00134954,0.9770169,0.0002353451,0.007643057,0.00001622508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805063,0.01173728,0.005436137,0.0002092295,0.0000633113,0.00005303071,0.0001987868,0.0000941504,0.001701753],"genre_scores_gemma":[0.9903566,0.005592847,0.002319291,0.0001332675,0.00002078965,0.00002697108,0.0001581185,0.000007787401,0.001384426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008759926,"threshold_uncertainty_score":0.002930462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00766186073448314,"score_gpt":0.2672182333518001,"score_spread":0.259556372617317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}