{"id":"W4414999257","doi":"10.1016/j.neo.2025.101237","title":"RANKL and CSF-1 are elevated in periovulatory follicular fluid of BRCA1 mutation carriers and increase proinflammatory signaling in fallopian tube epithelial cells","year":2025,"lang":"en","type":"article","venue":"Neoplasia","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Follicular fluid; Proinflammatory cytokine; Mutation; Germline mutation; Granulosa cell; Follicular phase; Fallopian tube cancer; Cytokine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283947,0.000201558,0.0002724708,0.0009044165,0.0002356855,0.0002755338,0.00008765675,0.0002008362,0.0008263191],"category_scores_gemma":[0.0006802693,0.0001181227,0.0001250552,0.0002534549,0.0001955559,0.0001116716,0.000151188,0.0001672537,0.0001110985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000167127,"about_ca_system_score_gemma":0.0001208594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046912,"about_ca_topic_score_gemma":0.0008932903,"domain_scores_codex":[0.9998752,0.00002219722,0.00001352368,0.000027614,0.00003340135,0.00002819427],"domain_scores_gemma":[0.999799,0.00004403599,0.00008610769,0.00000881187,0.00002093517,0.00004120117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001769631,0.0001249245,0.753714,0.00008933373,0.00006129673,0.002643135,0.0008816805,0.00009470853,0.2284878,0.0000450676,0.0001779375,0.01191044],"study_design_scores_gemma":[0.00002026729,0.0004959707,0.9803846,0.00001154793,0.00003558507,0.004691061,0.0005075004,0.0002896009,0.01304944,0.0000453973,0.0004615931,0.000007356151],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995477,0.0002920795,0.00003310946,0.000007751173,0.00000152442,0.000002957703,0.00004538887,0.00000245266,0.00006699492],"genre_scores_gemma":[0.9996425,0.00009781073,0.00008509881,0.000008795782,0.000004596026,0.000004061475,0.00006609192,8.761745e-7,0.00009003446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001046912,"threshold_uncertainty_score":0.002764344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004913740910251187,"score_gpt":0.2272030329449873,"score_spread":0.2222892920347361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}