{"id":"W4415005211","doi":"10.1016/j.jbc.2025.110796","title":"Direct coupling of lactate oxidation with butyryl-CoA formation via a canonical electron transfer flavoprotein in Fusobacterium nucleatum","year":2025,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kelowna General Hospital; Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Flavoprotein; Cofactor; Semiquinone; Redox; NAD+ kinase; Dehydrogenase; Flavin adenine dinucleotide; Flavin group","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001732332,0.0003016332,0.0002796716,0.00008878301,0.0001285488,0.0002826729,0.0002826772,0.0003649197,0.0002437692],"category_scores_gemma":[0.0002988293,0.0001167033,0.0002370239,0.0001112928,0.0001594641,0.0002620154,0.0003529564,0.000329869,0.0001024518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004516823,"about_ca_system_score_gemma":0.000153685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003241707,"about_ca_topic_score_gemma":0.002340231,"domain_scores_codex":[0.9997959,0.00003185282,0.00002075593,0.0000570852,0.00005556937,0.00003892568],"domain_scores_gemma":[0.9998875,0.00002969559,0.00002646276,0.00001381736,0.00002192219,0.00002057748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007093346,0.00001057997,0.0003716103,0.00002676063,0.000004023348,0.00004889172,0.00001669328,0.00004922751,0.9987029,0.00003471836,0.00001014662,0.000653407],"study_design_scores_gemma":[0.000007189038,0.0001408792,0.004740625,0.00000389878,0.000007075004,0.0001186527,0.00003445887,0.001241815,0.9931661,0.00004480565,0.000488176,0.000006297646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959278,0.000412549,0.003027308,0.00006193647,0.0000220615,0.00001555817,0.0001985364,0.00002819742,0.0003060344],"genre_scores_gemma":[0.9976248,0.0001382152,0.001720925,0.00001890109,0.000003670278,0.000009963766,0.0001818684,0.000005391749,0.0002962086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003241707,"threshold_uncertainty_score":0.006445706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00481567583870135,"score_gpt":0.2081563228785763,"score_spread":0.2033406470398749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}